DegronMD - Q8N0V3(RBFA)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D132E	TCGA-24-2290	OV	TCGA	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation altering degron motif	0.5647
p.D132E	DO30090	OV	ICGC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation altering degron motif	0.5647
p.E242K	TCGA-2F-A9KT	BLCA	TCGA	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.1111
p.R137L	TCGA-34-2604	LUSC	TCGA	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.R137L	DO26433	LUSC	ICGC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.V122A	TCGA-DF-A2KU	UCEC	TCGA	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122A	DO223286	UCEC	ICGC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.S233R	TCGA-E6-A1LX	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation altering degron motif	0.7427
p.S134L	DO869	BOCA	ICGC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation altering degron motif	0.7667
p.S231L	DO7977	COAD	ICGC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation altering degron motif	0.7667
p.S231L	DO26444	LUSC	ICGC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation altering degron motif	0.7667
p.S231L	BE-13	haematopoietic and lymphoid tissue	COSMIC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation altering degron motif	0.7667
p.A138V	DO233652	GACA	ICGC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.2222
p.G238A	DO12100	GBM	ICGC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.2222
p.G238A	MCC26	skin	COSMIC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.2222
p.G238V	DO229032	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.2222
p.C235F	DO229036	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.3056
p.W240C	DO229041	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.1667
p.W240L	DO229041	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.1667
p.W240G	DO218842	SKCA	ICGC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.1667
p.D119E	DO229227	THCA	ICGC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1111
p.G232V	DO42033	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation altering degron motif	0.7532
p.S222I	DO41235	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.1111
p.V122M	SIDM01090	Colorectal Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM00969	Ovarian Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM00846	Cervical Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM00849	Kidney Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM00254	Neuroblastoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM00875	Breast Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM00032	Bladder Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM00808	Burkitt's Lymphoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM01173	Rhabdomyosarcoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM00785	Acute Myeloid Leukemia	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM01409	Bladder Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM01254	Burkitt's Lymphoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.V122M	SIDM01525	Acute Myeloid Leukemia	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1944
p.A243V	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.0833
p.A243V	ACH-000357	Lymphoma	CCLE	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.0833
p.A243V	JEKO-1	haematopoietic and lymphoid tissue	COSMIC	PTTSS	DEG_SPOP_SBC_1	230:234	Mutation rewiring degron network	0.0833
p.R137P	SIDM00554	Ovarian Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.R137P	ACH-000524	Ovarian Cancer	CCLE	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.R137P	KURAMOCHI	ovary	COSMIC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.A138T	SIDM01608	Endometrial Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.2222
p.A138T	ACH-000990	Endometrial/Uterine Cancer	CCLE	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.2222
p.V127A	SIDM01394	Kidney Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	127:134	Mutation altering degron motif	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBFA

UniProt ID: Q8N0V3

Entrez ID: 79863

Protein name: Putative ribosome-binding factor A, mitochondrial

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RBFA in