DegronMD

Uniprot ID: Q8N0V3

Source protein: Putative ribosome-binding factor A, mitochondrial

Source gene: RBFA

Class: DEG_SCF_FBW7_1

Location: 127:134

E3 ligase: FBXW7

DEGRON score: 0.59

ASA_SCORE: 48.6125

COIL: 0.5396

CONS_SCORE: 0.6706

DSS_SCORE: 0.0874

HELIX: 0.0326

FCONS_SCORE: 1.1947

RIG_SCORE: 0.8207

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D132E	TCGA-24-2290	OV	TCGA	VSLTPDFS	DEG_SCF_FBW7_1	0.5647
p.D132E	DO30090	OV	ICGC	VSLTPDFS	DEG_SCF_FBW7_1	0.5647
p.R137L	TCGA-34-2604	LUSC	TCGA	VSLTPDFS	DEG_SCF_FBW7_1	0.25
p.R137L	DO26433	LUSC	ICGC	VSLTPDFS	DEG_SCF_FBW7_1	0.25
p.V122A	TCGA-DF-A2KU	UCEC	TCGA	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122A	DO223286	UCEC	ICGC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.S134L	DO869	BOCA	ICGC	VSLTPDFS	DEG_SCF_FBW7_1	0.7667
p.A138V	DO233652	GACA	ICGC	VSLTPDFS	DEG_SCF_FBW7_1	0.2222
p.D119E	DO229227	THCA	ICGC	VSLTPDFS	DEG_SCF_FBW7_1	0.1111
p.V122M	SIDM01090	Colorectal Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM00969	Ovarian Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM00846	Cervical Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM00849	Kidney Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM00254	Neuroblastoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM00875	Breast Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM00032	Bladder Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM00808	Burkitt's Lymphoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM01173	Rhabdomyosarcoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM00785	Acute Myeloid Leukemia	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM01409	Bladder Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM01254	Burkitt's Lymphoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.V122M	SIDM01525	Acute Myeloid Leukemia	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.1944
p.R137P	SIDM00554	Ovarian Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.25
p.R137P	ACH-000524	Ovarian Cancer	CCLE	VSLTPDFS	DEG_SCF_FBW7_1	0.25
p.R137P	KURAMOCHI	ovary	COSMIC	VSLTPDFS	DEG_SCF_FBW7_1	0.25
p.A138T	SIDM01608	Endometrial Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.2222
p.A138T	ACH-000990	Endometrial/Uterine Cancer	CCLE	VSLTPDFS	DEG_SCF_FBW7_1	0.2222
p.V127A	SIDM01394	Kidney Carcinoma	GDSC	VSLTPDFS	DEG_SCF_FBW7_1	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSLTPDFS

Degron related mutations and impact score

Drug responses associated with RBFA mutations

All proteins holding degron of VSLTPDFS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N0V3	Putative ribosome-binding factor A, mitochondrial	DEG_SCF_FBW7_1	127:134	VSLTPDFS	FBXW7	0.59	More...