DegronMD

Uniprot ID: O75333

Source protein: T-box transcription factor TBX10

Source gene: TBX10

Class: DEG_SPOP_SBC_1

Location: 21:25

E3 ligase: SPOP

DEGRON score: 0.988

ASA_SCORE: 69.78

COIL: 0.917

CONS_SCORE: 0.2652

DSS_SCORE: 0.5361

HELIX: 0.0262

FCONS_SCORE: 0.9612

RIG_SCORE: 0.6853

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P19T	TCGA-A5-A1OF	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.2778
p.P19T	DO42568	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.2778
p.R30Q	SIDM01076	B-Lymphoblastic Leukemia	GDSC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.R30Q	697	haematopoietic_and_lymphoid_tissue	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.E16D	SIDM00118	Colorectal Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.E16D	ACH-001081	Colon/Colorectal Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.1944
p.E16D	HCC2998	large_intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.G32R	DO233777	GACA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1389
p.S33L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.S33L	ACH-001127	Leukemia	CCLE	PTTSS	DEG_SPOP_SBC_1	0.1111
p.S33L	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.L12I	TCGA-E6-A1LX	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.0833
p.L12I	DO41020	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 13 of 13 entries

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Drug responses associated with TBX10 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PTTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2207:2211	PTTSS	SPOP	0.9961	More...
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	730:734	PTTSS	SPOP	0.9973	More...
Q9H3M9	Ataxin-3-like protein	DEG_SPOP_SBC_1	314:318	PTTSS	SPOP	0.999	More...
Q8N7W2	BEN domain-containing protein 7	DEG_SPOP_SBC_1	144:148	PTTSS	SPOP	0.6957	More...
Q9Y5J3	Hairy/enhancer-of-split related with YRPW motif protein 1	DEG_SPOP_SBC_1	41:45	PTTSS	SPOP	0.6104	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_SPOP_SBC_1	1590:1594	PTTSS	SPOP	0.9958	More...
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SPOP_SBC_1	238:242	PTTSS	SPOP	0.9196	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	549:553	PTTSS	SPOP	0.8155	More...
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SPOP_SBC_1	1250:1254	PTTSS	SPOP	0.9955	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6756:6760	PTTSS	SPOP	0.7898	More...
P55055	Oxysterols receptor LXR-beta	DEG_SPOP_SBC_1	4:8	PTTSS	SPOP	0.9972	More...
Q8N0V3	Putative ribosome-binding factor A, mitochondrial	DEG_SPOP_SBC_1	230:234	PTTSS	SPOP	0.9938	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	682:686	PTTSS	SPOP	0.8231	More...
Q9H254	Spectrin beta chain, non-erythrocytic 4	DEG_SPOP_SBC_1	2540:2544	PTTSS	SPOP	0.9961	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	21:25	PTTSS	SPOP	0.988	More...
Q7Z7G0	Target of Nesh-SH3	DEG_SPOP_SBC_1	341:345	PTTSS	SPOP	0.992	More...
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	261:265	PTTSS	SPOP	0.9948	More...
Q5JXX7	Transmembrane protein 31	DEG_SPOP_SBC_1	60:64	PTTSS	SPOP	0.5118	More...
Q15915	Zinc finger protein ZIC 1	DEG_SPOP_SBC_1	417:421	PTTSS	SPOP	0.9909	More...

Showing 1 to 19 of 19 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTSS

Degron related mutations and impact score

Drug responses associated with TBX10 mutations

All proteins holding degron of PTTSS