DegronMD - O75333(TBX10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P52S	TCGA-17-Z051	LUAD	TCGA	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.P19T	TCGA-A5-A1OF	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.2778
p.P19T	DO42568	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.2778
p.L12I	TCGA-E6-A1LX	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.0833
p.L12I	DO41020	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.0833
p.G32R	DO233777	GACA	ICGC	PTTSS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1389
p.G32R	DO233777	GACA	ICGC	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1389
p.P52L	DO50970	LICA	ICGC	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.A48P	SIDM00090	Ovarian Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.A48P	ACH-000696	Ovarian Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.A48P	OVCAR-8	ovary	COSMIC	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.R30Q	SIDM01076	B-Lymphoblastic Leukemia	GDSC	PTTSS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1944
p.R30Q	SIDM01076	B-Lymphoblastic Leukemia	GDSC	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.R30Q	697	haematopoietic and lymphoid tissue	COSMIC	PTTSS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1944
p.R30Q	697	haematopoietic and lymphoid tissue	COSMIC	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.G38V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.3056
p.G38V	ACH-001127	Leukemia	CCLE	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.3056
p.G38V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.3056
p.S33L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PTTSS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1111
p.S33L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.S33L	ACH-001127	Leukemia	CCLE	PTTSS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1111
p.S33L	ACH-001127	Leukemia	CCLE	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.S33L	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PTTSS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1111
p.S33L	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.E16D	SIDM00118	Colorectal Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1944
p.E16D	ACH-001081	Colon/Colorectal Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1944
p.E16D	HCC2998	large intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1944
p.A50V	ACH-001369	Ovarian Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1389

Kaplan plot for TBX10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBX10

UniProt ID: O75333

Entrez ID: 347853

Protein name: T-box transcription factor TBX10 (T-box protein 10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBX10 in