DegronMD

Uniprot ID: O75333

Source protein: T-box transcription factor TBX10

Source gene: TBX10

Class: DEG_SPOP_SBC_1

Location: 39:43

E3 ligase: SPOP

DEGRON score: 0.9955

ASA_SCORE: 74.46

COIL: 0.8898

CONS_SCORE: 0.3644

DSS_SCORE: 0.6131

HELIX: 0.0482

FCONS_SCORE: 1.2068

RIG_SCORE: 0.5992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P52S	TCGA-17-Z051	LUAD	TCGA	PCTSS	DEG_SPOP_SBC_1	0.0833
p.G32R	DO233777	GACA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.1389
p.P52L	DO50970	LICA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.0833
p.A48P	SIDM00090	Ovarian Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.1944
p.A48P	ACH-000696	Ovarian Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	0.1944
p.A48P	OVCAR-8	ovary	COSMIC	PCTSS	DEG_SPOP_SBC_1	0.1944
p.R30Q	SIDM01076	B-Lymphoblastic Leukemia	GDSC	PCTSS	DEG_SPOP_SBC_1	0.0833
p.R30Q	697	haematopoietic_and_lymphoid_tissue	COSMIC	PCTSS	DEG_SPOP_SBC_1	0.0833
p.G38V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.G38V	ACH-001127	Leukemia	CCLE	PCTSS	DEG_SPOP_SBC_1	0.3056
p.G38V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.S33L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PCTSS	DEG_SPOP_SBC_1	0.1667
p.S33L	ACH-001127	Leukemia	CCLE	PCTSS	DEG_SPOP_SBC_1	0.1667
p.S33L	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PCTSS	DEG_SPOP_SBC_1	0.1667
p.A50V	ACH-001369	Ovarian Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13952	Nuclear transcription factor Y subunit gamma	DEG_SPOP_SBC_1	344:348	PCTSS	SPOP	0.9867	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	260:264	PCTSS	SPOP	0.9248	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1747:1751	PCTSS	SPOP	0.9941	More...
Q15916	Zinc finger and BTB domain-containing protein 6	DEG_SPOP_SBC_1	238:242	PCTSS	SPOP	0.9861	More...
Q86TB3	Alpha-protein kinase 2	DEG_SPOP_SBC_1	1609:1613	PCTSS	SPOP	0.9968	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	1532:1536	PCTSS	SPOP	0.9333	More...
Q96H55	Unconventional myosin-XIX	DEG_SPOP_SBC_1	677:681	PCTSS	SPOP	0.8963	More...
Q9BZ71	Membrane-associated phosphatidylinositol transfer protein 3	DEG_SPOP_SBC_1	81:85	PCTSS	SPOP	0.9091	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	39:43	PCTSS	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons