DegronMD

Uniprot ID: Q14686

Source protein: Nuclear receptor coactivator 6

Source gene: NCOA6

Class: DEG_SPOP_SBC_1

Location: 1747:1751

E3 ligase: SPOP

DEGRON score: 0.9941

ASA_SCORE: 101.3

COIL: 0.9774

CONS_SCORE: 0.5804

DSS_SCORE: 0.6373

HELIX: 0.0094

FCONS_SCORE: 1.0297

RIG_SCORE: 0.5714

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1745F	TCGA-67-3771	LUAD	TCGA	PCTSS	DEG_SPOP_SBC_1	0.7222
p.S1745F	DO25797	LUAD	ICGC	PCTSS	DEG_SPOP_SBC_1	0.7222
p.S1751Y	TCGA-A5-A0GP	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.8231
p.S1751Y	DO41109	UCEC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.8231
p.S1756Y	TCGA-AA-A010	COAD	TCGA	PCTSS	DEG_SPOP_SBC_1	0.1944
p.P1747L	TCGA-D9-A1JW	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.7582
p.P1747L	DO37786	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.7582
p.P1755S	TCGA-DA-A1I8	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.2222
p.P1755S	DO37424	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.P1747S	TCGA-EB-A85J	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.6752
p.P1747S	DO50297	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.6752
p.P1740S	TCGA-EE-A2GC	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.1389
p.P1740S	DO37839	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.1389
p.P1744S	TCGA-GF-A6C9	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.25
p.P1744S	DO51254	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.25
p.Q1761K	DO229031	LICA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.0556
p.P1746S	DO220877	MELA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.P1758H	SIDM01526	Mesothelioma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.1389
p.P1758H	ACH-000086	Lung Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	0.1389
p.P1758H	ACH-002048	Sarcoma	CCLE	PCTSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13952	Nuclear transcription factor Y subunit gamma	DEG_SPOP_SBC_1	344:348	PCTSS	SPOP	0.9867	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	260:264	PCTSS	SPOP	0.9248	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1747:1751	PCTSS	SPOP	0.9941	More...
Q15916	Zinc finger and BTB domain-containing protein 6	DEG_SPOP_SBC_1	238:242	PCTSS	SPOP	0.9861	More...
Q86TB3	Alpha-protein kinase 2	DEG_SPOP_SBC_1	1609:1613	PCTSS	SPOP	0.9968	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	1532:1536	PCTSS	SPOP	0.9333	More...
Q96H55	Unconventional myosin-XIX	DEG_SPOP_SBC_1	677:681	PCTSS	SPOP	0.8963	More...
Q9BZ71	Membrane-associated phosphatidylinositol transfer protein 3	DEG_SPOP_SBC_1	81:85	PCTSS	SPOP	0.9091	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	39:43	PCTSS	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons