DegronMD - Q14140(SERTAD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S269L	TCGA-63-A5MB	LUSC	TCGA	PCTSS	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1944
p.S269L	DO52018	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1944
p.E177K	TCGA-AD-6890	COAD	TCGA	PTSTS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.2222
p.E177K	DO8039	COAD	ICGC	PTSTS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.2222
p.P273H	TCGA-AX-A2HD	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.0833
p.P273H	DO42608	UCEC	ICGC	PCTSS	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.0833
p.S185F	TCGA-C5-A8XH	CESC	TCGA	PTSTS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.7982
p.S185F	DO49898	CESC	ICGC	PTSTS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.7982
p.S183F	TCGA-C5-A902	CESC	TCGA	PTSTS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.7982
p.S183F	DO49916	CESC	ICGC	PTSTS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.7982
p.T190M	TCGA-D1-A15X	UCEC	TCGA	PTSTS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1944
p.T190M	DO43274	UCEC	ICGC	PTSTS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1944
p.C261Y	TCGA-DI-A1BU	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	260:264	Mutation altering degron motif	0.5976
p.C261Y	DO42023	UCEC	ICGC	PCTSS	DEG_SPOP_SBC_1	260:264	Mutation altering degron motif	0.5976
p.S254C	TCGA-DK-AA77	BLCA	TCGA	PCTSS	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1667
p.S254C	DO219014	BLCA	ICGC	PCTSS	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1667
p.P260S	TCGA-FW-A3R5	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	260:264	Mutation altering degron motif	0.6752
p.P260S	DO37406	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	260:264	Mutation altering degron motif	0.6752
p.T253M	TCGA-VQ-A94U	STAD	TCGA	PCTSS	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1389
p.T253M	DO222378	STAD	ICGC	PCTSS	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1389
p.A189V	DO230315	COCA	ICGC	PTSTS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.2222
p.S254P	DO220896	MELA	ICGC	PCTSS	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1667
p.A172V	DO229456	SKCA	ICGC	PTSTS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0833

Kaplan plot for SERTAD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SERTAD2

UniProt ID: Q14140

Entrez ID: 9792

Protein name: SERTA domain-containing protein 2 (Transcriptional regulator interacting with the PHD-bromodomain 2) (TRIP-Br2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SERTAD2 in