DegronMD

Uniprot ID: Q14140

Source protein: SERTA domain-containing protein 2

Source gene: SERTAD2

Class: DEG_SPOP_SBC_1

Location: 260:264

E3 ligase: SPOP

DEGRON score: 0.9248

ASA_SCORE: 56.34

COIL: 0.802

CONS_SCORE: 0.658

DSS_SCORE: 0.3344

HELIX: 0.141

FCONS_SCORE: 0.9568

RIG_SCORE: 0.7278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S269L	TCGA-63-A5MB	LUSC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.1944
p.S269L	DO52018	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.1944
p.P273H	TCGA-AX-A2HD	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.0833
p.P273H	DO42608	UCEC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.0833
p.C261Y	TCGA-DI-A1BU	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.5976
p.C261Y	DO42023	UCEC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.5976
p.S254C	TCGA-DK-AA77	BLCA	TCGA	PCTSS	DEG_SPOP_SBC_1	0.1667
p.S254C	DO219014	BLCA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.1667
p.P260S	TCGA-FW-A3R5	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.6752
p.P260S	DO37406	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.6752
p.T253M	TCGA-VQ-A94U	STAD	TCGA	PCTSS	DEG_SPOP_SBC_1	0.1389
p.T253M	DO222378	STAD	ICGC	PCTSS	DEG_SPOP_SBC_1	0.1389
p.S254P	DO220896	MELA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13952	Nuclear transcription factor Y subunit gamma	DEG_SPOP_SBC_1	344:348	PCTSS	SPOP	0.9867	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	260:264	PCTSS	SPOP	0.9248	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1747:1751	PCTSS	SPOP	0.9941	More...
Q15916	Zinc finger and BTB domain-containing protein 6	DEG_SPOP_SBC_1	238:242	PCTSS	SPOP	0.9861	More...
Q86TB3	Alpha-protein kinase 2	DEG_SPOP_SBC_1	1609:1613	PCTSS	SPOP	0.9968	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	1532:1536	PCTSS	SPOP	0.9333	More...
Q96H55	Unconventional myosin-XIX	DEG_SPOP_SBC_1	677:681	PCTSS	SPOP	0.8963	More...
Q9BZ71	Membrane-associated phosphatidylinositol transfer protein 3	DEG_SPOP_SBC_1	81:85	PCTSS	SPOP	0.9091	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	39:43	PCTSS	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons