DegronMD - Q96H55(MYO19)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y669C	TCGA-2W-A8YY	CESC	TCGA	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.1111
p.Y669C	DO223732	CESC	ICGC	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.1111
p.D684Y	TCGA-78-7160	LUAD	TCGA	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.25
p.D684Y	DO26180	LUAD	ICGC	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.25
p.P677L	TCGA-D3-A3MR	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation altering degron motif	0.7582
p.P677L	DO47256	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation altering degron motif	0.7582
p.G691A	TCGA-K4-A6MB	BLCA	TCGA	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.0556
p.G691A	DO44077	BLCA	ICGC	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.0556
p.A689D	SIDM02042	Pancreatic Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.1111
p.P688L	SIDM00253	Neuroblastoma	GDSC	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.1389
p.Y687F	SIDM00930	Osteosarcoma	GDSC	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.1667
p.Y687F	ACH-001715	Bone Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.1667
p.C678R	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation altering degron motif	0.719
p.C678R	SIDM01664	Prostate Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	677:681	Mutation altering degron motif	0.719

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons