DegronMD

Uniprot ID: Q96H55

Source protein: Unconventional myosin-XIX

Source gene: MYO19

Class: DEG_SPOP_SBC_1

Location: 677:681

E3 ligase: SPOP

DEGRON score: 0.8963

ASA_SCORE: 80.22

COIL: 0.9228

CONS_SCORE: 0.3798

DSS_SCORE: 0.3969

HELIX: 0.0414

FCONS_SCORE: 0.853

RIG_SCORE: 0.6401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y669C	TCGA-2W-A8YY	CESC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.1111
p.Y669C	DO223732	CESC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.1111
p.D684Y	TCGA-78-7160	LUAD	TCGA	PCTSS	DEG_SPOP_SBC_1	0.25
p.D684Y	DO26180	LUAD	ICGC	PCTSS	DEG_SPOP_SBC_1	0.25
p.P677L	TCGA-D3-A3MR	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.7582
p.P677L	DO47256	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.7582
p.G691A	TCGA-K4-A6MB	BLCA	TCGA	PCTSS	DEG_SPOP_SBC_1	0.0556
p.G691A	DO44077	BLCA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.0556
p.A689D	SIDM02042	Pancreatic Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.1111
p.P688L	SIDM00253	Neuroblastoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.1389
p.Y687F	SIDM00930	Osteosarcoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.1667
p.Y687F	ACH-001715	Bone Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	0.1667
p.C678R	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.719
p.C678R	SIDM01664	Prostate Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13952	Nuclear transcription factor Y subunit gamma	DEG_SPOP_SBC_1	344:348	PCTSS	SPOP	0.9867	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	260:264	PCTSS	SPOP	0.9248	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1747:1751	PCTSS	SPOP	0.9941	More...
Q15916	Zinc finger and BTB domain-containing protein 6	DEG_SPOP_SBC_1	238:242	PCTSS	SPOP	0.9861	More...
Q86TB3	Alpha-protein kinase 2	DEG_SPOP_SBC_1	1609:1613	PCTSS	SPOP	0.9968	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	1532:1536	PCTSS	SPOP	0.9333	More...
Q96H55	Unconventional myosin-XIX	DEG_SPOP_SBC_1	677:681	PCTSS	SPOP	0.8963	More...
Q9BZ71	Membrane-associated phosphatidylinositol transfer protein 3	DEG_SPOP_SBC_1	81:85	PCTSS	SPOP	0.9091	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	39:43	PCTSS	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons