DegronMD - Q9BZ71(PITPNM3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A280T	TCGA-AN-A0AK	BRCA	TCGA	PASSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.1389
p.A280T	DO1608	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.1389
p.E89K	TCGA-DA-A1I4	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.E89K	DO37655	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.G78E	TCGA-DF-A2KU	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.25
p.G78E	DO223286	UCEC	ICGC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.25
p.P81A	TCGA-HU-A4GQ	STAD	TCGA	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.6392
p.P81A	DO47767	STAD	ICGC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.6392
p.A80T	DO228483	BRCA	ICGC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056
p.A80T	DO230334	COCA	ICGC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056
p.A80T	DO229013	COCA	ICGC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056
p.A80T	DO229005	COCA	ICGC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056
p.A80T	DO229346	LAML	ICGC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056
p.A80T	DO229022	LICA	ICGC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056
p.A80T	DO230527	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056
p.A80T	DO231007	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056
p.A80T	DO231207	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056
p.A80V	DO230315	COCA	ICGC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056
p.A280V	DO222492	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.1389
p.A288D	DO222755	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	287:291	Mutation altering degron motif	0.6682
p.S291R	DO228900	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	287:291	Mutation altering degron motif	0.7427
p.P282T	DO229022	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.1944
p.D285V	DO229211	THCA	ICGC	PASSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.2778
p.R292W	SIDM00689	B-Lymphoblastic Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.3056
p.R292W	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.3056
p.R292W	JM1	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.3056
p.R292W	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.3056
p.P81S	SIDM00789	Colorectal Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.6752
p.P81S	ACH-000997	Colon/Colorectal Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.6752
p.P81S	ACH-001061	Colon/Colorectal Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.6752
p.P81S	HCT-15	large intestine	COSMIC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.6752
p.L87F	SIDM01205	Acute Myeloid Leukemia	GDSC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2778
p.L87F	ACH-002314	Leukemia	CCLE	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2778
p.L87F	TUR	haematopoietic and lymphoid tissue	COSMIC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2778
p.S285N	TALL-1	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.2778
p.P301L	OS-RC-2	kidney	COSMIC	PASSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.0556
p.E81K	TT	thyroid	COSMIC	PCTSS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.7022

Kaplan plot for PITPNM3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PITPNM3

UniProt ID: Q9BZ71

Entrez ID: 83394

Protein name: Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PITPNM3 in