DegronMD

Uniprot ID: Q9BZ71

Source protein: Membrane-associated phosphatidylinositol transfer protein 3

Source gene: PITPNM3

Class: DEG_SPOP_SBC_1

Location: 81:85

E3 ligase: SPOP

DEGRON score: 0.9091

ASA_SCORE: 58.88

COIL: 0.6876

CONS_SCORE: 0.2725

DSS_SCORE: 0.5706

HELIX: 0.243

FCONS_SCORE: 0.6835

RIG_SCORE: 0.7458

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E89K	TCGA-DA-A1I4	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.2222
p.E89K	DO37655	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.G78E	TCGA-DF-A2KU	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.25
p.G78E	DO223286	UCEC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.25
p.P81A	TCGA-HU-A4GQ	STAD	TCGA	PCTSS	DEG_SPOP_SBC_1	0.6392
p.P81A	DO47767	STAD	ICGC	PCTSS	DEG_SPOP_SBC_1	0.6392
p.A80T	DO228483	BRCA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.A80T	DO230334	COCA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.A80T	DO229013	COCA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.A80T	DO229005	COCA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.A80T	DO229346	LAML	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.A80T	DO229022	LICA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.A80T	DO230527	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.A80T	DO231007	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.A80T	DO231207	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.A80V	DO230315	COCA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.P81S	SIDM00789	Colorectal Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.6752
p.P81S	ACH-000997	Colon/Colorectal Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	0.6752
p.P81S	ACH-001061	Colon/Colorectal Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	0.6752
p.P81S	HCT-15	large_intestine	COSMIC	PCTSS	DEG_SPOP_SBC_1	0.6752
p.L87F	SIDM01205	Acute Myeloid Leukemia	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2778
p.L87F	ACH-002314	Leukemia	CCLE	PCTSS	DEG_SPOP_SBC_1	0.2778
p.L87F	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	PCTSS	DEG_SPOP_SBC_1	0.2778
p.E81K	TT	thyroid	COSMIC	PCTSS	DEG_SPOP_SBC_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13952	Nuclear transcription factor Y subunit gamma	DEG_SPOP_SBC_1	344:348	PCTSS	SPOP	0.9867	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	260:264	PCTSS	SPOP	0.9248	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1747:1751	PCTSS	SPOP	0.9941	More...
Q15916	Zinc finger and BTB domain-containing protein 6	DEG_SPOP_SBC_1	238:242	PCTSS	SPOP	0.9861	More...
Q86TB3	Alpha-protein kinase 2	DEG_SPOP_SBC_1	1609:1613	PCTSS	SPOP	0.9968	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	1532:1536	PCTSS	SPOP	0.9333	More...
Q96H55	Unconventional myosin-XIX	DEG_SPOP_SBC_1	677:681	PCTSS	SPOP	0.8963	More...
Q9BZ71	Membrane-associated phosphatidylinositol transfer protein 3	DEG_SPOP_SBC_1	81:85	PCTSS	SPOP	0.9091	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	39:43	PCTSS	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons