DegronMD

Uniprot ID: Q13952

Source protein: Nuclear transcription factor Y subunit gamma

Source gene: NFYC

Class: DEG_SPOP_SBC_1

Location: 344:348

E3 ligase: SPOP

DEGRON score: 0.9867

ASA_SCORE: 68.24

COIL: 0.7388

CONS_SCORE: 0.3282

DSS_SCORE: 0.5887

HELIX: 0.0582

FCONS_SCORE: 1.0328

RIG_SCORE: 0.6193

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q350H	TCGA-19-2621	GBM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.2778
p.P349S	TCGA-55-1592	LUAD	TCGA	PCTSS	DEG_SPOP_SBC_1	0.3056
p.P343S	TCGA-60-2703	LUSC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.75
p.P349L	TCGA-D3-A5GU	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.3056
p.G346R	TCGA-Q1-A6DW	CESC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.7568
p.V336L	DO224802	BRCA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.1111
p.P354T	DO222769	COCA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.1667
p.P355R	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.1389
p.P355R	ACH-000840	Lung Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	0.1389
p.P355R	HCC-366	lung	COSMIC	PCTSS	DEG_SPOP_SBC_1	0.1389
p.T343S	SIDM01237	Hepatocellular Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.75
p.T343S	ACH-001021	Liver Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	0.75
p.T343S	C3A	liver	COSMIC	PCTSS	DEG_SPOP_SBC_1	0.75
p.R334T	SIDM00485	Oral Cavity Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.0556
p.R334T	ACH-000794	Head and Neck Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	0.0556
p.R334T	BICR22	upper_aerodigestive_tract	COSMIC	PCTSS	DEG_SPOP_SBC_1	0.0556
p.E335K	ACH-000276	Breast Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	0.0833
p.E335G	ACH-000276	Breast Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	0.0833
p.P336R	HCC-366	lung	COSMIC	PCTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13952	Nuclear transcription factor Y subunit gamma	DEG_SPOP_SBC_1	344:348	PCTSS	SPOP	0.9867	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	260:264	PCTSS	SPOP	0.9248	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1747:1751	PCTSS	SPOP	0.9941	More...
Q15916	Zinc finger and BTB domain-containing protein 6	DEG_SPOP_SBC_1	238:242	PCTSS	SPOP	0.9861	More...
Q86TB3	Alpha-protein kinase 2	DEG_SPOP_SBC_1	1609:1613	PCTSS	SPOP	0.9968	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	1532:1536	PCTSS	SPOP	0.9333	More...
Q96H55	Unconventional myosin-XIX	DEG_SPOP_SBC_1	677:681	PCTSS	SPOP	0.8963	More...
Q9BZ71	Membrane-associated phosphatidylinositol transfer protein 3	DEG_SPOP_SBC_1	81:85	PCTSS	SPOP	0.9091	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	39:43	PCTSS	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons