DegronMD - Q86TB3(ALPK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L433F	TCGA-05-4396	LUAD	TCGA	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation altering degron motif	0.587
p.L433F	DO23838	LUAD	ICGC	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation altering degron motif	0.587
p.K1651N	TCGA-06-5416	GBM	TCGA	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation substituting flanking lysine	0.3056
p.K1651N	DO10880	GBM	ICGC	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation substituting flanking lysine	0.3056
p.I1632T	TCGA-37-3789	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0556
p.I1632T	DO26743	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0556
p.I1632T	SIDM00596	Endometrial Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0556
p.I1632T	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0556
p.I1632T	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0556
p.I1632T	HEC-1	endometrium	COSMIC	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0556
p.P1603S	TCGA-43-8118	LUSC	TCGA	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1667
p.P1603S	DO45471	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1667
p.P1603S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1667
p.P1603S	ACH-001127	Leukemia	CCLE	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1667
p.P1603S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1667
p.P1609S	TCGA-44-3917	LUAD	TCGA	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.6752
p.P1609S	TCGA-EB-A5FP	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.6752
p.P1609S	DO25242	LUAD	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.6752
p.P1609S	DO47362	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation altering degron motif	0.6752
p.P1600H	TCGA-56-8307	LUSC	TCGA	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0833
p.P1600H	DO219139	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0833
p.T17I	TCGA-66-2778	LUSC	TCGA	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.3056
p.T17I	DO27548	LUSC	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.3056
p.Q437K	TCGA-77-7463	LUSC	TCGA	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation altering degron motif	0.5833
p.Q437K	DO26716	LUSC	ICGC	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation altering degron motif	0.5833
p.H436Q	TCGA-77-7463	LUSC	TCGA	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation altering degron motif	0.7582
p.H436Q	DO26716	LUSC	ICGC	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation altering degron motif	0.7582
p.E1639D	TCGA-92-8065	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.25
p.E1639D	DO27074	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.25
p.R448I	TCGA-A5-A0G1	UCEC	TCGA	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation rewiring degron network	0.0556
p.R448I	DO42472	UCEC	ICGC	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation rewiring degron network	0.0556
p.L19I	TCGA-AA-A00N	COAD	TCGA	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.25
p.L19I	DO9876	COAD	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.25
p.L431H	TCGA-AB-2806	LAML	TCGA	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation rewiring degron network	0.2778
p.L431H	DO21283	LAML	ICGC	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation rewiring degron network	0.2778
p.S1649L	TCGA-AC-A23H	BRCA	TCGA	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.25
p.S1649L	DO2401	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.25
p.S1649L	DO222868	MELA	ICGC	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.25
p.D1620Y	TCGA-AJ-A3EK	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1389
p.D1620Y	DO41584	UCEC	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1389
p.S16Y	TCGA-AP-A1DR	UCEC	TCGA	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.712
p.S16Y	DO43747	UCEC	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.712
p.I1637V	TCGA-BG-A222	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.1944
p.I1637V	DO42977	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.1944
p.Q437P	TCGA-BS-A0UJ	UCEC	TCGA	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation altering degron motif	0.5924
p.Q437P	DO42745	UCEC	ICGC	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation altering degron motif	0.5924
p.L1599F	TCGA-CN-6010	HNSC	TCGA	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0556
p.L1599F	DO14766	HNSC	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0556
p.L1599F	DO231165	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0556
p.G1616E	TCGA-DA-A1IC	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.25
p.G1616E	DO37430	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.25
p.A1654T	TCGA-EE-A29D	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.1111
p.A1654T	DO38123	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.1111
p.P1614L	TCGA-EE-A29S	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.3056
p.P1614L	DO37936	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.3056
p.P1614S	TCGA-EE-A29S	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.3056
p.P1614S	DO37936	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.3056
p.G439R	TCGA-EE-A2A5	SKCM	TCGA	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation rewiring degron network	0.3056
p.G439R	DO37941	SKCM	ICGC	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation rewiring degron network	0.3056
p.I1623T	TCGA-F5-6814	READ	TCGA	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0556
p.I1623T	DO36556	READ	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0556
p.S16C	TCGA-G2-AA3B	BLCA	TCGA	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.7541
p.S16C	DO51882	BLCA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.7541
p.P435H	TCGA-GN-A263	SKCM	TCGA	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation altering degron motif	0.7694
p.P435H	DO37766	SKCM	ICGC	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation altering degron motif	0.7694
p.E445K	TCGA-IA-A83W	KIRP	TCGA	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation rewiring degron network	0.1389
p.E445K	DO51566	KIRP	ICGC	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation rewiring degron network	0.1389
p.D1620N	TCGA-W3-AA1V	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1389
p.D1620N	DO51276	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1389
p.K2T	DO229010	COCA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation substituting flanking lysine	0.2778
p.K2T	DO229013	COCA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation substituting flanking lysine	0.2778
p.K2T	DO229016	COCA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation substituting flanking lysine	0.2778
p.K2T	DO229003	COCA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation substituting flanking lysine	0.2778
p.K2T	DO229005	COCA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation substituting flanking lysine	0.2778
p.A1650V	DO234156	ESAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.2222
p.R1607S	DO223153	ESCA	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.2778
p.P11Q	DO229029	LICA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.5924
p.P10L	DO229050	LICA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6471
p.P10L	SIDM01128	Small Cell Lung Carcinoma	GDSC	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6471
p.P10L	ACH-000767	Lung Cancer	CCLE	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6471
p.P10L	NCI-H526	lung	COSMIC	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6471
p.P1600S	DO231165	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.0833
p.P1642L	SIDM00620	Glioblastoma	GDSC	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation altering degron motif	0.7582
p.P1642L	ACH-002226	Brain Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation altering degron motif	0.7582
p.P1642L	D-336MG	central nervous system	COSMIC	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation altering degron motif	0.7582
p.G434E	SIDM00217	Colorectal Carcinoma	GDSC	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation altering degron motif	0.6087
p.G434E	ACH-000999	Colon/Colorectal Cancer	CCLE	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation altering degron motif	0.6087
p.G434E	SNU-1040	large intestine	COSMIC	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation altering degron motif	0.6087
p.T427S	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation rewiring degron network	0.1667
p.T427S	ACH-000912	Lung Cancer	CCLE	LGPHQD	LIG_APCC_ABBA_1	433:438	Mutation rewiring degron network	0.1667
p.V1618I	ACH-000960	Leukemia	CCLE	PCTSS	DEG_SPOP_SBC_1	1609:1613	Mutation rewiring degron network	0.1944
p.S1644R	ACH-001128	Rhabdoid	CCLE	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation altering degron motif	0.7427
p.E5K	ACH-001786	Colon/Colorectal Cancer	CCLE	QRPPLCFLS	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.25
p.L1653S	ACH-002048	Sarcoma	CCLE	PPSSS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALPK2

UniProt ID: Q86TB3

Entrez ID: 115701

Protein name: Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ALPK2 in