DegronMD

Uniprot ID: Q86TB3

Source protein: Alpha-protein kinase 2

Source gene: ALPK2

Class: DEG_APCC_DBOX_1

Location: 8:16

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8583

ASA_SCORE: 69.6889

COIL: 0.5897

CONS_SCORE: 0.2873

DSS_SCORE: 0.4673

HELIX: 0.0191

FCONS_SCORE: 0.9095

RIG_SCORE: 0.7697

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T17I	TCGA-66-2778	LUSC	TCGA	QRPPLCFLS	DEG_APCC_DBOX_1	0.3056
p.T17I	DO27548	LUSC	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	0.3056
p.L19I	TCGA-AA-A00N	COAD	TCGA	QRPPLCFLS	DEG_APCC_DBOX_1	0.25
p.L19I	DO9876	COAD	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	0.25
p.S16Y	TCGA-AP-A1DR	UCEC	TCGA	QRPPLCFLS	DEG_APCC_DBOX_1	0.712
p.S16Y	DO43747	UCEC	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	0.712
p.S16C	TCGA-G2-AA3B	BLCA	TCGA	QRPPLCFLS	DEG_APCC_DBOX_1	0.7541
p.S16C	DO51882	BLCA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	0.7541
p.K2T	DO229010	COCA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	0.2778
p.K2T	DO229013	COCA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	0.2778
p.K2T	DO229016	COCA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	0.2778
p.K2T	DO229003	COCA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	0.2778
p.K2T	DO229005	COCA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	0.2778
p.P11Q	DO229029	LICA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	0.5924
p.P10L	DO229050	LICA	ICGC	QRPPLCFLS	DEG_APCC_DBOX_1	0.6471
p.P10L	SIDM01128	Small Cell Lung Carcinoma	GDSC	QRPPLCFLS	DEG_APCC_DBOX_1	0.6471
p.P10L	ACH-000767	Lung Cancer	CCLE	QRPPLCFLS	DEG_APCC_DBOX_1	0.6471
p.P10L	NCI-H526	lung	COSMIC	QRPPLCFLS	DEG_APCC_DBOX_1	0.6471
p.E5K	ACH-001786	Colon/Colorectal Cancer	CCLE	QRPPLCFLS	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86TB3	Alpha-protein kinase 2	DEG_APCC_DBOX_1	8:16	QRPPLCFLS	APC,CDC20,FZR1	0.8583	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons