DegronMD

Uniprot ID: Q86TB3

Source protein: Alpha-protein kinase 2

Source gene: ALPK2

Class: DEG_SPOP_SBC_1

Location: 1609:1613

E3 ligase: SPOP

DEGRON score: 0.9968

ASA_SCORE: 74.46

COIL: 0.9208

CONS_SCORE: 0.8407

DSS_SCORE: 0.5943

HELIX: 0.02

FCONS_SCORE: 1.3109

RIG_SCORE: 0.6625

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1603S	TCGA-43-8118	LUSC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.1667
p.P1603S	DO45471	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.1667
p.P1603S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PCTSS	DEG_SPOP_SBC_1	0.1667
p.P1603S	ACH-001127	Leukemia	CCLE	PCTSS	DEG_SPOP_SBC_1	0.1667
p.P1603S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PCTSS	DEG_SPOP_SBC_1	0.1667
p.P1609S	TCGA-44-3917	LUAD	TCGA	PCTSS	DEG_SPOP_SBC_1	0.6752
p.P1609S	TCGA-EB-A5FP	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.6752
p.P1609S	DO25242	LUAD	ICGC	PCTSS	DEG_SPOP_SBC_1	0.6752
p.P1609S	DO47362	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.6752
p.P1600H	TCGA-56-8307	LUSC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.0833
p.P1600H	DO219139	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.0833
p.D1620Y	TCGA-AJ-A3EK	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.1389
p.D1620Y	DO41584	UCEC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.1389
p.L1599F	TCGA-CN-6010	HNSC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.0556
p.L1599F	DO14766	HNSC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.0556
p.L1599F	DO231165	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.0556
p.G1616E	TCGA-DA-A1IC	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.25
p.G1616E	DO37430	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.25
p.P1614L	TCGA-EE-A29S	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.3056
p.P1614L	DO37936	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.P1614S	TCGA-EE-A29S	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.3056
p.P1614S	DO37936	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.I1623T	TCGA-F5-6814	READ	TCGA	PCTSS	DEG_SPOP_SBC_1	0.0556
p.I1623T	DO36556	READ	ICGC	PCTSS	DEG_SPOP_SBC_1	0.0556
p.D1620N	TCGA-W3-AA1V	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.1389
p.D1620N	DO51276	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.1389
p.R1607S	DO223153	ESCA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.2778
p.P1600S	DO231165	LUSC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.0833
p.V1618I	ACH-000960	Leukemia	CCLE	PCTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13952	Nuclear transcription factor Y subunit gamma	DEG_SPOP_SBC_1	344:348	PCTSS	SPOP	0.9867	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	260:264	PCTSS	SPOP	0.9248	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1747:1751	PCTSS	SPOP	0.9941	More...
Q15916	Zinc finger and BTB domain-containing protein 6	DEG_SPOP_SBC_1	238:242	PCTSS	SPOP	0.9861	More...
Q86TB3	Alpha-protein kinase 2	DEG_SPOP_SBC_1	1609:1613	PCTSS	SPOP	0.9968	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	1532:1536	PCTSS	SPOP	0.9333	More...
Q96H55	Unconventional myosin-XIX	DEG_SPOP_SBC_1	677:681	PCTSS	SPOP	0.8963	More...
Q9BZ71	Membrane-associated phosphatidylinositol transfer protein 3	DEG_SPOP_SBC_1	81:85	PCTSS	SPOP	0.9091	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	39:43	PCTSS	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCTSS

Degron related mutations and impact score

Drug responses associated with ALPK2 mutations

All proteins holding degron of PCTSS