DegronMD

Uniprot ID: Q15916

Source protein: Zinc finger and BTB domain-containing protein 6

Source gene: ZBTB6

Class: DEG_SPOP_SBC_1

Location: 238:242

E3 ligase: SPOP

DEGRON score: 0.9861

ASA_SCORE: 62.96

COIL: 0.8164

CONS_SCORE: 0.7974

DSS_SCORE: 0.3681

HELIX: 0.0464

FCONS_SCORE: 1.2282

RIG_SCORE: 0.736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G229C	TCGA-AA-3966	COAD	TCGA	PCTSS	DEG_SPOP_SBC_1	0.0833
p.G229C	DO10068	COAD	ICGC	PCTSS	DEG_SPOP_SBC_1	0.0833
p.S236L	TCGA-C5-A7UH	CESC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.2778
p.S236L	DO49891	CESC	ICGC	PCTSS	DEG_SPOP_SBC_1	0.2778
p.Q237L	DO222363	MELA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.3056
p.S249C	DO232445	PBCA	ICGC	PCTSS	DEG_SPOP_SBC_1	0.1389
p.M246I	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.M246I	SIDM00717	Non-Cancerous	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.M246I	SIDM00620	Glioblastoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.M246I	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.M246I	SIDM00832	Colorectal Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.M246I	SIDM01149	Small Cell Lung Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.M246I	SIDM00835	Colorectal Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.M246I	SIDM00733	Small Cell Lung Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.M246I	SIDM00522	Small Cell Lung Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.M246I	SIDM00103	Mesothelioma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.M246I	SIDM01101	Neuroblastoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.M246I	SIDM00079	Ovarian Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.M246I	SIDM01560	Rhabdomyosarcoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.2222
p.F248L	SIDM01611	Endometrial Carcinoma	GDSC	PCTSS	DEG_SPOP_SBC_1	0.1667
p.F248L	ACH-000996	Endometrial/Uterine Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13952	Nuclear transcription factor Y subunit gamma	DEG_SPOP_SBC_1	344:348	PCTSS	SPOP	0.9867	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	260:264	PCTSS	SPOP	0.9248	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1747:1751	PCTSS	SPOP	0.9941	More...
Q15916	Zinc finger and BTB domain-containing protein 6	DEG_SPOP_SBC_1	238:242	PCTSS	SPOP	0.9861	More...
Q86TB3	Alpha-protein kinase 2	DEG_SPOP_SBC_1	1609:1613	PCTSS	SPOP	0.9968	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	1532:1536	PCTSS	SPOP	0.9333	More...
Q96H55	Unconventional myosin-XIX	DEG_SPOP_SBC_1	677:681	PCTSS	SPOP	0.8963	More...
Q9BZ71	Membrane-associated phosphatidylinositol transfer protein 3	DEG_SPOP_SBC_1	81:85	PCTSS	SPOP	0.9091	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	39:43	PCTSS	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons