DegronMD - Q14686(NCOA6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1717T	TCGA-06-5416	GBM	TCGA	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation altering degron motif	0.7139
p.A1717T	DO10880	GBM	ICGC	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation altering degron motif	0.7139
p.S1803Y	TCGA-13-0897	OV	TCGA	PVSSS	DEG_SPOP_SBC_1	1810:1814	Mutation rewiring degron network	0.1389
p.S1803Y	DO29558	OV	ICGC	PVSSS	DEG_SPOP_SBC_1	1810:1814	Mutation rewiring degron network	0.1389
p.A1610T	TCGA-2H-A9GL	ESCA	TCGA	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.3056
p.S1745F	TCGA-67-3771	LUAD	TCGA	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation blocking phosphorylation signal	0.7222
p.S1745F	DO25797	LUAD	ICGC	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation blocking phosphorylation signal	0.7222
p.L363F	TCGA-69-7765	LUAD	TCGA	ARPSLATVQ	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.6981
p.L363F	DO23580	LUAD	ICGC	ARPSLATVQ	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.6981
p.P242S	TCGA-85-A50Z	LUSC	TCGA	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.5641
p.P242S	DO45462	LUSC	ICGC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.5641
p.A386G	TCGA-98-8021	LUSC	TCGA	PPPY	ITCH	373:376	Mutation rewiring degron network	0.0556
p.A386G	DO27468	LUSC	ICGC	PPPY	ITCH	373:376	Mutation rewiring degron network	0.0556
p.S235Y	TCGA-A5-A0G1	UCEC	TCGA	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation rewiring degron network	0.3056
p.S235Y	DO42472	UCEC	ICGC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation rewiring degron network	0.3056
p.S1751Y	TCGA-A5-A0GP	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation altering degron motif	0.8231
p.S1751Y	DO41109	UCEC	ICGC	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation altering degron motif	0.8231
p.S535L	TCGA-A5-A0GP	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7667
p.S535L	TCGA-DG-A2KL	CESC	TCGA	VPSTT	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7667
p.S535L	TCGA-FW-A3R5	SKCM	TCGA	VPSTT	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7667
p.S535L	DO51596	CESC	ICGC	VPSTT	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7667
p.S535L	DO37406	SKCM	ICGC	VPSTT	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7667
p.S535L	DO41109	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7667
p.G351S	TCGA-A6-6781	COAD	TCGA	ARPSLATVQ	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1111
p.G351S	TCGA-D5-6530	COAD	TCGA	ARPSLATVQ	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1111
p.G351S	DO8447	COAD	ICGC	ARPSLATVQ	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1111
p.G351S	DO8312	COAD	ICGC	ARPSLATVQ	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1111
p.P1098S	TCGA-AA-3510	COAD	TCGA	PVNTPLGS	DEG_SCF_FBW7_1	1100:1107	Mutation rewiring degron network	0.2778
p.P1098S	DO7783	COAD	ICGC	PVNTPLGS	DEG_SCF_FBW7_1	1100:1107	Mutation rewiring degron network	0.2778
p.A2054V	TCGA-AA-3966	COAD	TCGA	ASSST	DEG_SPOP_SBC_1	2044:2048	Mutation rewiring degron network	0.1667
p.A2054V	DO10068	COAD	ICGC	ASSST	DEG_SPOP_SBC_1	2044:2048	Mutation rewiring degron network	0.1667
p.S1756Y	TCGA-AA-A010	COAD	TCGA	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation rewiring degron network	0.1944
p.R1808Q	TCGA-AC-A23H	BRCA	TCGA	PVSSS	DEG_SPOP_SBC_1	1810:1814	Mutation rewiring degron network	0.2778
p.R1808Q	DO224618	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	1810:1814	Mutation rewiring degron network	0.2778
p.R1808Q	DO1016	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	1810:1814	Mutation rewiring degron network	0.2778
p.R1808Q	DO2401	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	1810:1814	Mutation rewiring degron network	0.2778
p.S1709Y	TCGA-AG-A002	READ	TCGA	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.1111
p.S1709Y	TCGA-CA-6718	COAD	TCGA	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.1111
p.S1709Y	TCGA-EO-A22R	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.1111
p.S1709Y	DO7801	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.1111
p.S1709Y	DO42713	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.1111
p.Q1119H	TCGA-AG-A002	READ	TCGA	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation rewiring degron network	0.25
p.S1124L	TCGA-AJ-A3BD	UCEC	TCGA	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation rewiring degron network	0.1111
p.S1124L	DO40813	UCEC	ICGC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation rewiring degron network	0.1111
p.P1118L	TCGA-AJ-A3EK	UCEC	TCGA	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation rewiring degron network	0.2778
p.P1118L	TCGA-BS-A0UF	UCEC	TCGA	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation rewiring degron network	0.2778
p.P1118L	TCGA-FP-A4BE	STAD	TCGA	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation rewiring degron network	0.2778
p.P1118L	DO48016	STAD	ICGC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation rewiring degron network	0.2778
p.P1118L	DO41584	UCEC	ICGC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation rewiring degron network	0.2778
p.P1118L	DO41488	UCEC	ICGC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation rewiring degron network	0.2778
p.R1581I	TCGA-AJ-A3EL	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.3056
p.R1581I	DO41542	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.3056
p.R2035C	TCGA-AN-A046	BRCA	TCGA	ASSST	DEG_SPOP_SBC_1	2044:2048	Mutation rewiring degron network	0.0833
p.R2035C	DO1285	BRCA	ICGC	ASSST	DEG_SPOP_SBC_1	2044:2048	Mutation rewiring degron network	0.0833
p.R2035C	SIDM01050	Biliary Tract Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	2044:2048	Mutation rewiring degron network	0.0833
p.R2035C	SIDM00534	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	2044:2048	Mutation rewiring degron network	0.0833
p.R2035C	ACH-000986	Colon/Colorectal Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	2044:2048	Mutation rewiring degron network	0.0833
p.R2035C	ACH-001494	Bile Duct Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	2044:2048	Mutation rewiring degron network	0.0833
p.R1730Q	TCGA-B5-A0JV	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.0833
p.R1730Q	DO43979	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.0833
p.V533M	TCGA-B5-A1MX	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7208
p.V533M	DO41999	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	533:537	Mutation altering degron motif	0.7208
p.A1723P	TCGA-BR-6452	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.2778
p.A1723P	DO38404	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.2778
p.P1591L	TCGA-CC-A7II	LIHC	TCGA	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1944
p.P1591L	DO52182	LIHC	ICGC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1944
p.P1591L	SIDM00003	Melanoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1944
p.P1591L	ACH-000884	Skin Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1944
p.P1591L	ACH-002159	Skin Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1944
p.P1591L	M14	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1944
p.N249S	TCGA-CK-4951	COAD	TCGA	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation rewiring degron network	0.3056
p.N249S	DO10582	COAD	ICGC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation rewiring degron network	0.3056
p.K1707T	TCGA-D1-A16X	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation substituting flanking lysine	0.1667
p.K1707T	DO41799	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation substituting flanking lysine	0.1667
p.P258L	TCGA-D3-A5GO	SKCM	TCGA	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation rewiring degron network	0.0556
p.P258L	DO47419	SKCM	ICGC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation rewiring degron network	0.0556
p.P1747L	TCGA-D9-A1JW	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation altering degron motif	0.7582
p.P1747L	DO37786	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation altering degron motif	0.7582
p.P1755S	TCGA-DA-A1I8	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation rewiring degron network	0.2222
p.P1755S	DO37424	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation rewiring degron network	0.2222
p.P1605L	TCGA-DU-6407	LGG	TCGA	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation altering degron motif	0.7582
p.P1605L	DO22295	LGG	ICGC	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation altering degron motif	0.7582
p.S1589F	TCGA-EB-A41A	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.25
p.S1589F	DO37429	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.25
p.P1747S	TCGA-EB-A85J	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation altering degron motif	0.6752
p.P1747S	DO50297	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation altering degron motif	0.6752
p.P1740S	TCGA-EE-A2GC	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation rewiring degron network	0.1389
p.P1740S	DO37839	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation rewiring degron network	0.1389
p.S1812L	TCGA-EO-A3AZ	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	1810:1814	Mutation altering degron motif	0.7667
p.S1812L	DO50078	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	1810:1814	Mutation altering degron motif	0.7667
p.P1125S	TCGA-FI-A2D5	UCEC	TCGA	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation rewiring degron network	0.0833
p.P1125S	DO41331	UCEC	ICGC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation rewiring degron network	0.0833
p.P374S	TCGA-FW-A3R5	SKCM	TCGA	PPPY	ITCH	373:376	Mutation altering degron motif	0.6752
p.P374S	DO37406	SKCM	ICGC	PPPY	ITCH	373:376	Mutation altering degron motif	0.6752
p.G972C	TCGA-G4-6302	COAD	TCGA	PPGY	ITCH	970:973	Mutation altering degron motif	0.6489
p.G972C	DO8778	COAD	ICGC	PPGY	ITCH	970:973	Mutation altering degron motif	0.6489
p.P1744S	TCGA-GF-A6C9	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation rewiring degron network	0.25
p.P1744S	DO51254	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation rewiring degron network	0.25
p.V1820M	TCGA-N9-A4Q1	UCS	TCGA	PVSSS	DEG_SPOP_SBC_1	1810:1814	Mutation rewiring degron network	0.1667
p.Q1596E	DO225334	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.0556
p.Q1596E	DO225334	BRCA	ICGC	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.0833
p.G531S	DO229325	BTCA	ICGC	VPSTT	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.2778
p.P982S	DO10324	COAD	ICGC	PPGY	ITCH	970:973	Mutation rewiring degron network	0.0833
p.F1600C	DO8264	COAD	ICGC	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.1944
p.M353I	DO230342	COCA	ICGC	ARPSLATVQ	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1667
p.S1613A	DO222762	COCA	ICGC	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.2222
p.V1713I	DO222630	ESCA	ICGC	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.2222
p.F1600L	DO233088	GACA	ICGC	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.1944
p.P1576H	DO233823	GACA	ICGC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1667
p.P982T	DO228978	LICA	ICGC	PPGY	ITCH	970:973	Mutation rewiring degron network	0.0833
p.P982T	DO229018	LICA	ICGC	PPGY	ITCH	970:973	Mutation rewiring degron network	0.0833
p.A1614E	DO229022	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.1944
p.Q1761K	DO229031	LICA	ICGC	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation rewiring degron network	0.0556
p.A546D	DO229034	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0833
p.P1617T	DO229037	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.1111
p.H231N	DO229045	LICA	ICGC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation rewiring degron network	0.1944
p.P1593L	DO23242	LINC	ICGC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1389
p.P970R	DO23102	LINC	ICGC	PPGY	ITCH	970:973	Mutation altering degron motif	0.7512
p.V1583I	DO229177	LMS	ICGC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation altering degron motif	0.5965
p.P239R	DO231075	LUSC	ICGC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM01151	Hepatocellular Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM00607	Glioblastoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM00596	Endometrial Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM00245	Small Cell Lung Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM01210	Glioblastoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM00368	Small Cell Lung Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM00566	Oral Cavity Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM00560	Gastric Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM01444	Glioblastoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM01776	Plasma Cell Myeloma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM01472	Hepatocellular Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM01464	Pancreatic Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM01469	Pancreatic Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM00161	Biliary Tract Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM01448	Head and Neck Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P239R	SIDM01559	Melanoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6401
p.P974S	DO220852	MELA	ICGC	PPGY	ITCH	970:973	Mutation rewiring degron network	0.3056
p.P1746S	DO220877	MELA	ICGC	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation rewiring degron network	0.3056
p.P1576S	DO222363	MELA	ICGC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1667
p.P1724A	DO229146	NKTL	ICGC	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.25
p.T1602I	DO218861	SKCA	ICGC	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.25
p.S1709C	DO231467	THCA	ICGC	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.1111
p.P377S	SIDM00403	T-Lymphoblastic Leukemia	GDSC	ARPSLATVQ	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.0556
p.P377S	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	373:376	Mutation rewiring degron network	0.3056
p.P377S	ACH-000636	Leukemia	CCLE	ARPSLATVQ	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.0556
p.P377S	ACH-000636	Leukemia	CCLE	PPPY	ITCH	373:376	Mutation rewiring degron network	0.3056
p.P377S	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	ARPSLATVQ	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.0556
p.P377S	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	373:376	Mutation rewiring degron network	0.3056
p.S247P	SIDM00845	Burkitt's Lymphoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.5641
p.S1107N	SIDM00525	Osteosarcoma	GDSC	PVNTPLGS	DEG_SCF_FBW7_1	1100:1107	Mutation altering degron motif	0.7069
p.S1107N	ACH-000359	Bone Cancer	CCLE	PVNTPLGS	DEG_SCF_FBW7_1	1100:1107	Mutation altering degron motif	0.7069
p.S1107N	MG-63	bone	COSMIC	PVNTPLGS	DEG_SCF_FBW7_1	1100:1107	Mutation altering degron motif	0.7069
p.S1123T	SIDM00848	Ewing's Sarcoma	GDSC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation rewiring degron network	0.1389
p.R969Q	SIDM00583	Pancreatic Carcinoma	GDSC	PPGY	ITCH	970:973	Mutation rewiring degron network	0.3056
p.R969Q	KP-1N	pancreas	COSMIC	PPGY	ITCH	970:973	Mutation rewiring degron network	0.3056
p.P1593T	SIDM01157	Other Solid Cancers	GDSC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1389
p.P1593T	ACH-001400	Cervical Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1389
p.P1593T	SW954	vulva	COSMIC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1389
p.P1722S	SIDM01146	Gastric Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.3056
p.P1722S	ACH-000932	Gastric Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.3056
p.P1722S	NCI-SNU-1	stomach	COSMIC	ALSSS	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.3056
p.S2038C	SIDM00898	Breast Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	2044:2048	Mutation blocking phosphorylation signal	0.6111
p.S2038C	ACH-000017	Breast Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	2044:2048	Mutation blocking phosphorylation signal	0.6111
p.S2038C	ACH-000248	Breast Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	2044:2048	Mutation blocking phosphorylation signal	0.6111
p.S2038C	AU565	breast	COSMIC	ASSST	DEG_SPOP_SBC_1	2044:2048	Mutation blocking phosphorylation signal	0.6111
p.P350S	SIDM01653	Non-Cancerous	GDSC	ARPSLATVQ	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.0833
p.P350S	ACH-002351	Non-Cancerous	CCLE	ARPSLATVQ	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.0833
p.S1584N	SIDM00542	Glioblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation altering degron motif	0.7069
p.N1604S	SIDM00621	Ewing's Sarcoma	GDSC	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.3056
p.N1604S	ACH-002113	Bone Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.3056
p.N1604S	EW-13	bone	COSMIC	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.3056
p.H371Q	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	ARPSLATVQ	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.2222
p.H371Q	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	373:376	Mutation rewiring degron network	0.2778
p.I1597T	SIDM01608	Endometrial Carcinoma	GDSC	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.1111
p.I1597T	ACH-000990	Endometrial/Uterine Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.1111
p.R981S	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	PPGY	ITCH	970:973	Mutation rewiring degron network	0.1111
p.P1758H	SIDM01526	Mesothelioma	GDSC	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation rewiring degron network	0.1389
p.P1758H	ACH-000086	Lung Cancer	CCLE	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation rewiring degron network	0.1389
p.P1758H	ACH-002048	Sarcoma	CCLE	PCTSS	DEG_SPOP_SBC_1	1747:1751	Mutation rewiring degron network	0.1389
p.T1618A	SIDM01777	Pancreatic Carcinoma	GDSC	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.0833
p.T1618A	ACH-000093	Pancreatic Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.0833
p.R981M	ACH-000936	Ovarian Cancer	CCLE	PPGY	ITCH	970:973	Mutation rewiring degron network	0.1111
p.M1112R	ACH-000991	Colon/Colorectal Cancer	CCLE	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation altering degron motif	0.7521
p.M1112R	SNU-81	large intestine	COSMIC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	1110:1116	Mutation altering degron motif	0.7521
p.M243V	ACH-001617	Lymphoma	CCLE	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6097
p.M243V	OCI-LY7	haematopoietic and lymphoid tissue	COSMIC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	236:248	Mutation altering degron motif	0.6097
p.F1600S	ACH-001719	Ovarian Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.1944
p.S1574N	NCI-H630	large intestine	COSMIC	PVSSS	DEG_SPOP_SBC_1	1582:1586	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCOA6

UniProt ID: Q14686

Entrez ID: 23054

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCOA6 in