DegronMD

Uniprot ID: Q14686

Source protein: Nuclear receptor coactivator 6

Source gene: NCOA6

Class: DEG_SPOP_SBC_1

Location: 1605:1609

E3 ligase: SPOP

DEGRON score: 0.9763

ASA_SCORE: 102.32

COIL: 0.9638

CONS_SCORE: 0.5911

DSS_SCORE: 0.3206

HELIX: 0.0182

FCONS_SCORE: 0.9842

RIG_SCORE: 0.7415

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1610T	TCGA-2H-A9GL	ESCA	TCGA	PITTS	DEG_SPOP_SBC_1	0.3056
p.P1605L	TCGA-DU-6407	LGG	TCGA	PITTS	DEG_SPOP_SBC_1	0.7582
p.P1605L	DO22295	LGG	ICGC	PITTS	DEG_SPOP_SBC_1	0.7582
p.Q1596E	DO225334	BRCA	ICGC	PITTS	DEG_SPOP_SBC_1	0.0833
p.F1600C	DO8264	COAD	ICGC	PITTS	DEG_SPOP_SBC_1	0.1944
p.S1613A	DO222762	COCA	ICGC	PITTS	DEG_SPOP_SBC_1	0.2222
p.F1600L	DO233088	GACA	ICGC	PITTS	DEG_SPOP_SBC_1	0.1944
p.A1614E	DO229022	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.1944
p.P1617T	DO229037	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.1111
p.T1602I	DO218861	SKCA	ICGC	PITTS	DEG_SPOP_SBC_1	0.25
p.N1604S	SIDM00621	Ewing's Sarcoma	GDSC	PITTS	DEG_SPOP_SBC_1	0.3056
p.N1604S	ACH-002113	Bone Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	0.3056
p.N1604S	EW-13	bone	COSMIC	PITTS	DEG_SPOP_SBC_1	0.3056
p.I1597T	SIDM01608	Endometrial Carcinoma	GDSC	PITTS	DEG_SPOP_SBC_1	0.1111
p.I1597T	ACH-000990	Endometrial/Uterine Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	0.1111
p.T1618A	SIDM01777	Pancreatic Carcinoma	GDSC	PITTS	DEG_SPOP_SBC_1	0.0833
p.T1618A	ACH-000093	Pancreatic Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	0.0833
p.F1600S	ACH-001719	Ovarian Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28562	Dual specificity protein phosphatase 1	DEG_SPOP_SBC_1	360:364	PITTS	SPOP	0.5301	More...
Q13115	Dual specificity protein phosphatase 4	DEG_SPOP_SBC_1	387:391	PITTS	SPOP	0.6022	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1605:1609	PITTS	SPOP	0.9763	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	566:570	PITTS	SPOP	0.9482	More...
Q93073	Selenocysteine insertion sequence-binding protein 2-like	DEG_SPOP_SBC_1	435:439	PITTS	SPOP	0.9768	More...
Q9NUC0	SERTA domain-containing protein 4	DEG_SPOP_SBC_1	68:72	PITTS	SPOP	0.9703	More...
Q9ULE4	Protein FAM184B	DEG_SPOP_SBC_1	1000:1004	PITTS	SPOP	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons