DegronMD

Uniprot ID: Q9UMN6

Source protein: Histone-lysine N-methyltransferase 2B

Source gene: KMT2B

Class: DEG_SPOP_SBC_1

Location: 566:570

E3 ligase: SPOP

DEGRON score: 0.9482

ASA_SCORE: 99.2

COIL: 0.9638

CONS_SCORE: 0.2809

DSS_SCORE: 0.6515

HELIX: 0.0102

FCONS_SCORE: 0.8623

RIG_SCORE: 0.5704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S560L	TCGA-43-8118	LUSC	TCGA	PITTS	DEG_SPOP_SBC_1	0.1667
p.S560L	TCGA-E7-A7XN	BLCA	TCGA	PITTS	DEG_SPOP_SBC_1	0.1667
p.S560L	DO51878	BLCA	ICGC	PITTS	DEG_SPOP_SBC_1	0.1667
p.S560L	DO45471	LUSC	ICGC	PITTS	DEG_SPOP_SBC_1	0.1667
p.P579L	TCGA-BG-A220	UCEC	TCGA	PITTS	DEG_SPOP_SBC_1	0.0833
p.P579L	DO41784	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	0.0833
p.P572H	TCGA-CV-6953	HNSC	TCGA	PITTS	DEG_SPOP_SBC_1	0.2778
p.P572H	DO14278	HNSC	ICGC	PITTS	DEG_SPOP_SBC_1	0.2778
p.P574L	TCGA-W3-AA1O	SKCM	TCGA	PITTS	DEG_SPOP_SBC_1	0.2222
p.P574L	DO51274	SKCM	ICGC	PITTS	DEG_SPOP_SBC_1	0.2222
p.S563L	DO229389	BTCA	ICGC	PITTS	DEG_SPOP_SBC_1	0.25
p.S563L	DO37410	SKCM	ICGC	PITTS	DEG_SPOP_SBC_1	0.25
p.T578M	DO220258	SARC	ICGC	PITTS	DEG_SPOP_SBC_1	0.1111
p.C560Y	DO42033	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28562	Dual specificity protein phosphatase 1	DEG_SPOP_SBC_1	360:364	PITTS	SPOP	0.5301	More...
Q13115	Dual specificity protein phosphatase 4	DEG_SPOP_SBC_1	387:391	PITTS	SPOP	0.6022	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1605:1609	PITTS	SPOP	0.9763	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	566:570	PITTS	SPOP	0.9482	More...
Q93073	Selenocysteine insertion sequence-binding protein 2-like	DEG_SPOP_SBC_1	435:439	PITTS	SPOP	0.9768	More...
Q9NUC0	SERTA domain-containing protein 4	DEG_SPOP_SBC_1	68:72	PITTS	SPOP	0.9703	More...
Q9ULE4	Protein FAM184B	DEG_SPOP_SBC_1	1000:1004	PITTS	SPOP	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons