DegronMD

Uniprot ID: Q9ULE4

Source protein: Protein FAM184B

Source gene: FAM184B

Class: DEG_SPOP_SBC_1

Location: 1000:1004

E3 ligase: SPOP

DEGRON score: 0.9946

ASA_SCORE: 93.56

COIL: 0.9612

CONS_SCORE: 0.7569

DSS_SCORE: 0.6055

HELIX: 0.0092

FCONS_SCORE: 1.0292

RIG_SCORE: 0.647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D991N	TCGA-AJ-A3EL	UCEC	TCGA	PITTS	DEG_SPOP_SBC_1	0.0833
p.D991N	DO41542	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	0.0833
p.S993I	TCGA-EO-A22U	UCEC	TCGA	PITTS	DEG_SPOP_SBC_1	0.1389
p.S993I	DO43755	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	0.1389
p.A998D	DO228976	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.2778
p.P1005H	DO229015	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.3056
p.P1005T	DO229032	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.3056
p.P1005T	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PITTS	DEG_SPOP_SBC_1	0.3056
p.T1003K	DO229038	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.8417
p.A998T	SIDM00282	Colorectal Carcinoma	GDSC	PITTS	DEG_SPOP_SBC_1	0.2778
p.A998T	ACH-000998	Colon/Colorectal Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	0.2778
p.A998T	CW-2	large_intestine	COSMIC	PITTS	DEG_SPOP_SBC_1	0.2778
p.P999H	ACH-000897	Thyroid Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	0.3056
p.G1014D	ACH-002069	Bone Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28562	Dual specificity protein phosphatase 1	DEG_SPOP_SBC_1	360:364	PITTS	SPOP	0.5301	More...
Q13115	Dual specificity protein phosphatase 4	DEG_SPOP_SBC_1	387:391	PITTS	SPOP	0.6022	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1605:1609	PITTS	SPOP	0.9763	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	566:570	PITTS	SPOP	0.9482	More...
Q93073	Selenocysteine insertion sequence-binding protein 2-like	DEG_SPOP_SBC_1	435:439	PITTS	SPOP	0.9768	More...
Q9NUC0	SERTA domain-containing protein 4	DEG_SPOP_SBC_1	68:72	PITTS	SPOP	0.9703	More...
Q9ULE4	Protein FAM184B	DEG_SPOP_SBC_1	1000:1004	PITTS	SPOP	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons