DegronMD

Uniprot ID: Q9NUC0

Source protein: SERTA domain-containing protein 4

Source gene: SERTAD4

Class: DEG_SPOP_SBC_1

Location: 68:72

E3 ligase: SPOP

DEGRON score: 0.9703

ASA_SCORE: 69.12

COIL: 0.6784

CONS_SCORE: 0.5478

DSS_SCORE: 0.3416

HELIX: 0.0572

FCONS_SCORE: 0.8563

RIG_SCORE: 0.74

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T71A	TCGA-06-5416	GBM	TCGA	PITTS	DEG_SPOP_SBC_1	0.7139
p.T71A	DO10880	GBM	ICGC	PITTS	DEG_SPOP_SBC_1	0.7139
p.T71I	TCGA-G3-A5SL	LIHC	TCGA	PITTS	DEG_SPOP_SBC_1	0.7078
p.T71I	DO44978	LIHC	ICGC	PITTS	DEG_SPOP_SBC_1	0.7078
p.R79S	DO228252	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.1389
p.R79M	DO228976	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.1389
p.A58S	DO228985	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.0556
p.A58S	DO229045	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.0556
p.R63S	DO229026	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.1944
p.S66P	SIDM00845	Burkitt's Lymphoma	GDSC	PITTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28562	Dual specificity protein phosphatase 1	DEG_SPOP_SBC_1	360:364	PITTS	SPOP	0.5301	More...
Q13115	Dual specificity protein phosphatase 4	DEG_SPOP_SBC_1	387:391	PITTS	SPOP	0.6022	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1605:1609	PITTS	SPOP	0.9763	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	566:570	PITTS	SPOP	0.9482	More...
Q93073	Selenocysteine insertion sequence-binding protein 2-like	DEG_SPOP_SBC_1	435:439	PITTS	SPOP	0.9768	More...
Q9NUC0	SERTA domain-containing protein 4	DEG_SPOP_SBC_1	68:72	PITTS	SPOP	0.9703	More...
Q9ULE4	Protein FAM184B	DEG_SPOP_SBC_1	1000:1004	PITTS	SPOP	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons