DegronMD - Q9ULE4(FAM184B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D991N	TCGA-AJ-A3EL	UCEC	TCGA	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation rewiring degron network	0.0833
p.D991N	DO41542	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation rewiring degron network	0.0833
p.S993I	TCGA-EO-A22U	UCEC	TCGA	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation rewiring degron network	0.1389
p.S993I	DO43755	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation rewiring degron network	0.1389
p.A998D	DO228976	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation rewiring degron network	0.2778
p.P1005H	DO229015	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation rewiring degron network	0.3056
p.P1005T	DO229032	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation rewiring degron network	0.3056
p.P1005T	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation rewiring degron network	0.3056
p.T1003K	DO229038	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation altering degron motif	0.8417
p.A998T	SIDM00282	Colorectal Carcinoma	GDSC	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation rewiring degron network	0.2778
p.A998T	ACH-000998	Colon/Colorectal Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation rewiring degron network	0.2778
p.A998T	CW-2	large intestine	COSMIC	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation rewiring degron network	0.2778
p.P999H	ACH-000897	Thyroid Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation rewiring degron network	0.3056
p.G1014D	ACH-002069	Bone Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	1000:1004	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons