DUSP4
UniProt ID: Q13115
Entrez ID: 1846
Protein name: Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)
External links: UniprotKB HGNC RefSeq COSMIC
Please click HERE
for better display.
FUNCTION: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. {ECO:0000269|PubMed:7535768}....
FUNCTION: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. {ECO:0000269|PubMed:7535768}.
View more >>
GO - Biological processes (BP):
dephosphorylation [GO:0016311]; endoderm formation [GO:0001706]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]...
dephosphorylation [GO:0016311]; endoderm formation [GO:0001706]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]
View more >>
GO - Molecular function (MF):
MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine/threonine phosphatase activity [GO:0008330]; protein tyrosine p...
MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine/threonine phosphatase activity [GO:0008330]; protein tyrosine phosphatase activity [GO:0004725]
View more >>
GO - Cellular component (CC):
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
View more >>
DUSP4
Control panel
Show dataset:
Show Degron:
All sites
Degron
Degron
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for DUSP4 in
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc