DegronMD

Uniprot ID: Q13115

Source protein: Dual specificity protein phosphatase 4

Source gene: DUSP4

Class: DEG_SPOP_SBC_1

Location: 387:391

E3 ligase: SPOP

DEGRON score: 0.6022

ASA_SCORE: 93.46

COIL: 0.955

CONS_SCORE: 0.4131

DSS_SCORE: 0.5807

HELIX: 0.0162

FCONS_SCORE: 1.091

RIG_SCORE: 0.6927

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S386N	TCGA-AP-A0LI	UCEC	TCGA	PITTS	DEG_SPOP_SBC_1	0.75
p.S386N	DO43658	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	0.75
p.S380R	DO228976	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.1389
p.P382L	DO27943	ORCA	ICGC	PITTS	DEG_SPOP_SBC_1	0.1944
p.S393R	DO232224	PBCA	ICGC	PITTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28562	Dual specificity protein phosphatase 1	DEG_SPOP_SBC_1	360:364	PITTS	SPOP	0.5301	More...
Q13115	Dual specificity protein phosphatase 4	DEG_SPOP_SBC_1	387:391	PITTS	SPOP	0.6022	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1605:1609	PITTS	SPOP	0.9763	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	566:570	PITTS	SPOP	0.9482	More...
Q93073	Selenocysteine insertion sequence-binding protein 2-like	DEG_SPOP_SBC_1	435:439	PITTS	SPOP	0.9768	More...
Q9NUC0	SERTA domain-containing protein 4	DEG_SPOP_SBC_1	68:72	PITTS	SPOP	0.9703	More...
Q9ULE4	Protein FAM184B	DEG_SPOP_SBC_1	1000:1004	PITTS	SPOP	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons