DegronMD

Uniprot ID: P28562

Source protein: Dual specificity protein phosphatase 1

Source gene: DUSP1

Class: DEG_SPOP_SBC_1

Location: 360:364

E3 ligase: SPOP

DEGRON score: 0.5301

ASA_SCORE: 90.18

COIL: 0.939

CONS_SCORE: 0.3455

DSS_SCORE: 0.5811

HELIX: 0.0182

FCONS_SCORE: 1.044

RIG_SCORE: 0.7154

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N351S	TCGA-AB-2899	LAML	TCGA	PITTS	DEG_SPOP_SBC_1	0.0833
p.N351S	DO21529	LAML	ICGC	PITTS	DEG_SPOP_SBC_1	0.0833
p.S352R	TCGA-AP-A0LH	UCEC	TCGA	PITTS	DEG_SPOP_SBC_1	0.1111
p.S352R	DO41080	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	0.1111
p.L354P	TCGA-CG-5721	STAD	TCGA	PITTS	DEG_SPOP_SBC_1	0.1667
p.L354P	DO38192	STAD	ICGC	PITTS	DEG_SPOP_SBC_1	0.1667
p.A353V	TCGA-S9-A7IS	LGG	TCGA	PITTS	DEG_SPOP_SBC_1	0.1389
p.A353V	DO48606	LGG	ICGC	PITTS	DEG_SPOP_SBC_1	0.1389
p.S364Y	SIDM01611	Endometrial Carcinoma	GDSC	PITTS	DEG_SPOP_SBC_1	0.8231
p.S364Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	0.8231

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28562	Dual specificity protein phosphatase 1	DEG_SPOP_SBC_1	360:364	PITTS	SPOP	0.5301	More...
Q13115	Dual specificity protein phosphatase 4	DEG_SPOP_SBC_1	387:391	PITTS	SPOP	0.6022	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1605:1609	PITTS	SPOP	0.9763	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	566:570	PITTS	SPOP	0.9482	More...
Q93073	Selenocysteine insertion sequence-binding protein 2-like	DEG_SPOP_SBC_1	435:439	PITTS	SPOP	0.9768	More...
Q9NUC0	SERTA domain-containing protein 4	DEG_SPOP_SBC_1	68:72	PITTS	SPOP	0.9703	More...
Q9ULE4	Protein FAM184B	DEG_SPOP_SBC_1	1000:1004	PITTS	SPOP	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons