DegronMD - P28562(DUSP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N351S	TCGA-AB-2899	LAML	TCGA	PITTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0833
p.N351S	DO21529	LAML	ICGC	PITTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0833
p.S352R	TCGA-AP-A0LH	UCEC	TCGA	PITTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1111
p.S352R	DO41080	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1111
p.L354P	TCGA-CG-5721	STAD	TCGA	PITTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1667
p.L354P	DO38192	STAD	ICGC	PITTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1667
p.P142T	TCGA-EE-A29Q	SKCM	TCGA	PLSTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1667
p.P142T	DO37866	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1667
p.G160W	TCGA-ER-A19F	SKCM	TCGA	PLSTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.G160W	DO37679	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.A353V	TCGA-S9-A7IS	LGG	TCGA	PITTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1389
p.A353V	DO48606	LGG	ICGC	PITTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1389
p.L147I	DO232876	PEME	ICGC	PLSTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.S152G	SIDM01608	Endometrial Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.6993
p.S152G	ACH-000990	Endometrial/Uterine Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.6993
p.S364Y	SIDM01611	Endometrial Carcinoma	GDSC	PITTS	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.8231
p.S364Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	PITTS	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.8231
p.S156I	SIDM01611	Endometrial Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2222
p.S156I	ACH-000996	Endometrial/Uterine Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2222
p.S140L	ACH-001061	Colon/Colorectal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	148:152	Mutation blocking phosphorylation signal	0.5556

Kaplan plot for DUSP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DUSP1

UniProt ID: P28562

Entrez ID: 1843

Protein name: Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DUSP1 in