DegronMD

Uniprot ID: Q93073

Source protein: Selenocysteine insertion sequence-binding protein 2-like

Source gene: SECISBP2L

Class: DEG_SPOP_SBC_1

Location: 435:439

E3 ligase: SPOP

DEGRON score: 0.9768

ASA_SCORE: 94.38

COIL: 0.9366

CONS_SCORE: 0.3172

DSS_SCORE: 0.4253

HELIX: 0.041

FCONS_SCORE: 0.9463

RIG_SCORE: 0.7627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K449N	TCGA-AP-A056	UCEC	TCGA	PITTS	DEG_SPOP_SBC_1	0.1667
p.K449N	DO43971	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	0.1667
p.P433Q	TCGA-CA-6717	COAD	TCGA	PITTS	DEG_SPOP_SBC_1	0.2778
p.P433L	TCGA-FS-A4FC	SKCM	TCGA	PITTS	DEG_SPOP_SBC_1	0.2778
p.P441H	TCGA-GN-A26D	SKCM	TCGA	PITTS	DEG_SPOP_SBC_1	0.2778
p.P441H	DO37480	SKCM	ICGC	PITTS	DEG_SPOP_SBC_1	0.2778
p.A430D	DO223732	CESC	ICGC	PITTS	DEG_SPOP_SBC_1	0.1944
p.K433R	DO9346	COAD	ICGC	PITTS	DEG_SPOP_SBC_1	0.2778
p.T432N	DO228948	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.25
p.R443S	DO229035	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.2222
p.A444E	DO229038	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	0.1944
p.K425T	DO41799	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	0.5
p.I436V	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PITTS	DEG_SPOP_SBC_1	0.5965
p.Q428H	NCI-H2030	lung	COSMIC	PITTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28562	Dual specificity protein phosphatase 1	DEG_SPOP_SBC_1	360:364	PITTS	SPOP	0.5301	More...
Q13115	Dual specificity protein phosphatase 4	DEG_SPOP_SBC_1	387:391	PITTS	SPOP	0.6022	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1605:1609	PITTS	SPOP	0.9763	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	566:570	PITTS	SPOP	0.9482	More...
Q93073	Selenocysteine insertion sequence-binding protein 2-like	DEG_SPOP_SBC_1	435:439	PITTS	SPOP	0.9768	More...
Q9NUC0	SERTA domain-containing protein 4	DEG_SPOP_SBC_1	68:72	PITTS	SPOP	0.9703	More...
Q9ULE4	Protein FAM184B	DEG_SPOP_SBC_1	1000:1004	PITTS	SPOP	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons