DegronMD - Q93073(SECISBP2L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C57R	TCGA-A6-A565	COAD	TCGA	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1944
p.C57R	DO44090	COAD	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1944
p.S52N	TCGA-AJ-A5DW	UCEC	TCGA	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7069
p.S52N	DO50075	UCEC	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.7069
p.K449N	TCGA-AP-A056	UCEC	TCGA	PITTS	DEG_SPOP_SBC_1	435:439	Mutation substituting flanking lysine	0.1667
p.K449N	DO43971	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	435:439	Mutation substituting flanking lysine	0.1667
p.S258P	TCGA-AX-A063	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.6752
p.S258P	DO42201	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.6752
p.P433Q	TCGA-CA-6717	COAD	TCGA	PITTS	DEG_SPOP_SBC_1	435:439	Mutation rewiring degron network	0.2778
p.D267N	TCGA-D1-A16Y	UCEC	TCGA	DSGYCS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.2222
p.D267N	TCGA-D1-A16Y	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.D267N	DO41524	UCEC	ICGC	DSGYCS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.2222
p.D267N	DO41524	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.D267N	SIDM00534	Colorectal Carcinoma	GDSC	DSGYCS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.2222
p.D267N	SIDM00534	Colorectal Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.D267N	ACH-000986	Colon/Colorectal Cancer	CCLE	DSGYCS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.2222
p.D267N	ACH-000986	Colon/Colorectal Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.D267N	HT-115	large intestine	COSMIC	DSGYCS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.2222
p.D267N	HT-115	large intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.P36Q	TCGA-D3-A2JB	SKCM	TCGA	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0833
p.P36Q	DO47607	SKCM	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.0833
p.G245D	TCGA-DJ-A13L	THCA	TCGA	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.0556
p.G245D	DO219585	THCA	ICGC	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.0556
p.P51H	TCGA-EE-A29P	SKCM	TCGA	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6583
p.P51H	DO37916	SKCM	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6583
p.I50F	TCGA-EJ-5522	PRAD	TCGA	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6304
p.I50F	DO36307	PRAD	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.6304
p.P253R	TCGA-EP-A2KA	LIHC	TCGA	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.2778
p.P253R	DO23023	LIHC	ICGC	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.2778
p.Q261H	TCGA-FD-A3SL	BLCA	TCGA	DSGYCS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.0556
p.Q261H	TCGA-FD-A3SL	BLCA	TCGA	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.2778
p.Q261H	DO732	BLCA	ICGC	DSGYCS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.0556
p.Q261H	DO732	BLCA	ICGC	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.2778
p.D38N	TCGA-FD-A3SP	BLCA	TCGA	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1389
p.D38N	DO594	BLCA	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1389
p.P433L	TCGA-FS-A4FC	SKCM	TCGA	PITTS	DEG_SPOP_SBC_1	435:439	Mutation rewiring degron network	0.2778
p.P441H	TCGA-GN-A26D	SKCM	TCGA	PITTS	DEG_SPOP_SBC_1	435:439	Mutation rewiring degron network	0.2778
p.P441H	DO37480	SKCM	ICGC	PITTS	DEG_SPOP_SBC_1	435:439	Mutation rewiring degron network	0.2778
p.R247K	TCGA-MV-A51V	BLCA	TCGA	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.R247K	DO474	BLCA	ICGC	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.R249T	TCGA-VS-A8EI	CESC	TCGA	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1667
p.R249T	DO51621	CESC	ICGC	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1667
p.A430D	DO223732	CESC	ICGC	PITTS	DEG_SPOP_SBC_1	435:439	Mutation rewiring degron network	0.1944
p.K433R	DO9346	COAD	ICGC	PITTS	DEG_SPOP_SBC_1	435:439	Mutation rewiring degron network	0.2778
p.I55M	DO222765	COCA	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.25
p.D269E	DO228948	LICA	ICGC	DSGYCS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.2778
p.D269E	DO228948	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.0556
p.T432N	DO228948	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	435:439	Mutation rewiring degron network	0.25
p.R443S	DO229035	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	435:439	Mutation rewiring degron network	0.2222
p.A444E	DO229038	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	435:439	Mutation rewiring degron network	0.1944
p.I50V	DO32825	PACA	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation altering degron motif	0.5965
p.K425T	DO41799	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	435:439	Mutation blocking phosphorylation signal	0.5
p.Y58C	DO41199	UCEC	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	45:52	Mutation rewiring degron network	0.1667
p.I436V	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PITTS	DEG_SPOP_SBC_1	435:439	Mutation altering degron motif	0.5965
p.A266V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	DSGYCS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.1944
p.A266V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1389
p.A266V	ACH-000929	Lung Cancer	CCLE	DSGYCS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.1944
p.A266V	ACH-000929	Lung Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1389
p.A266V	NCI-H2110	lung	COSMIC	DSGYCS	DEG_SCF_TRCP1_1	271:276	Mutation rewiring degron network	0.1944
p.A266V	NCI-H2110	lung	COSMIC	AESSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1389
p.Q428H	NCI-H2030	lung	COSMIC	PITTS	DEG_SPOP_SBC_1	435:439	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SECISBP2L

UniProt ID: Q93073

Entrez ID: 9728

Protein name: Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SECISBP2L in