DegronMD

Uniprot ID: Q93073

Source protein: Selenocysteine insertion sequence-binding protein 2-like

Source gene: SECISBP2L

Class: DEG_SCF_TRCP1_1

Location: 271:276

E3 ligase: BTRC

DEGRON score: 0.9985

ASA_SCORE: 77.35

COIL: 0.899

CONS_SCORE: 0.3325

DSS_SCORE: 0.6233

HELIX: 0.0537

FCONS_SCORE: 1.0089

RIG_SCORE: 0.5926

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D267N	TCGA-D1-A16Y	UCEC	TCGA	DSGYCS	DEG_SCF_TRCP1_1	0.2222
p.D267N	DO41524	UCEC	ICGC	DSGYCS	DEG_SCF_TRCP1_1	0.2222
p.D267N	SIDM00534	Colorectal Carcinoma	GDSC	DSGYCS	DEG_SCF_TRCP1_1	0.2222
p.D267N	ACH-000986	Colon/Colorectal Cancer	CCLE	DSGYCS	DEG_SCF_TRCP1_1	0.2222
p.D267N	HT-115	large_intestine	COSMIC	DSGYCS	DEG_SCF_TRCP1_1	0.2222
p.Q261H	TCGA-FD-A3SL	BLCA	TCGA	DSGYCS	DEG_SCF_TRCP1_1	0.0556
p.Q261H	DO732	BLCA	ICGC	DSGYCS	DEG_SCF_TRCP1_1	0.0556
p.D269E	DO228948	LICA	ICGC	DSGYCS	DEG_SCF_TRCP1_1	0.2778
p.A266V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	DSGYCS	DEG_SCF_TRCP1_1	0.1944
p.A266V	ACH-000929	Lung Cancer	CCLE	DSGYCS	DEG_SCF_TRCP1_1	0.1944
p.A266V	NCI-H2110	lung	COSMIC	DSGYCS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q93073	Selenocysteine insertion sequence-binding protein 2-like	DEG_SCF_TRCP1_1	271:276	DSGYCS	BTRC	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons