DegronMD

Uniprot ID: Q93073

Source protein: Selenocysteine insertion sequence-binding protein 2-like

Source gene: SECISBP2L

Class: DEG_SCF_FBW7_1

Location: 45:52

E3 ligase: FBXW7

DEGRON score: 0.9668

ASA_SCORE: 71.8625

COIL: 0.9099

CONS_SCORE: 0.3378

DSS_SCORE: 0.2987

HELIX: 0.0385

FCONS_SCORE: 1.0134

RIG_SCORE: 0.7277

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C57R	TCGA-A6-A565	COAD	TCGA	VEPTPIPS	DEG_SCF_FBW7_1	0.1944
p.C57R	DO44090	COAD	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	0.1944
p.S52N	TCGA-AJ-A5DW	UCEC	TCGA	VEPTPIPS	DEG_SCF_FBW7_1	0.7069
p.S52N	DO50075	UCEC	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	0.7069
p.P36Q	TCGA-D3-A2JB	SKCM	TCGA	VEPTPIPS	DEG_SCF_FBW7_1	0.0833
p.P36Q	DO47607	SKCM	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	0.0833
p.P51H	TCGA-EE-A29P	SKCM	TCGA	VEPTPIPS	DEG_SCF_FBW7_1	0.6583
p.P51H	DO37916	SKCM	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	0.6583
p.I50F	TCGA-EJ-5522	PRAD	TCGA	VEPTPIPS	DEG_SCF_FBW7_1	0.6304
p.I50F	DO36307	PRAD	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	0.6304
p.D38N	TCGA-FD-A3SP	BLCA	TCGA	VEPTPIPS	DEG_SCF_FBW7_1	0.1389
p.D38N	DO594	BLCA	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	0.1389
p.I55M	DO222765	COCA	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	0.25
p.I50V	DO32825	PACA	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	0.5965
p.Y58C	DO41199	UCEC	ICGC	VEPTPIPS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q93073	Selenocysteine insertion sequence-binding protein 2-like	DEG_SCF_FBW7_1	45:52	VEPTPIPS	FBXW7	0.9668	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons