DegronMD - Q9UMN6(KMT2B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q2368H	TCGA-37-3792	LUSC	TCGA	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.1667
p.Q2368H	DO233267	GACA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.1667
p.Q2368H	DO27192	LUSC	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.1667
p.R179L	TCGA-39-5034	LUSC	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.25
p.R179L	DO26854	LUSC	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.25
p.P160H	TCGA-41-2575	GBM	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.0833
p.P160H	DO10874	GBM	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.0833
p.S560L	TCGA-43-8118	LUSC	TCGA	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1667
p.S560L	TCGA-E7-A7XN	BLCA	TCGA	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1667
p.S560L	DO51878	BLCA	ICGC	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1667
p.S560L	DO45471	LUSC	ICGC	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1667
p.S955Y	TCGA-62-8399	LUAD	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.25
p.S955Y	DO24606	LUAD	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.25
p.P419H	TCGA-A8-A07C	BRCA	TCGA	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation altering degron motif	0.7694
p.P419H	DO4713	BRCA	ICGC	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation altering degron motif	0.7694
p.R181W	TCGA-AA-3492	COAD	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.1944
p.R181W	DO8224	COAD	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.1944
p.R181W	DO233737	GACA	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.1944
p.K959N	TCGA-AA-A010	COAD	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation substituting flanking lysine	0.25
p.D168Y	TCGA-AJ-A5DW	UCEC	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.3056
p.D168Y	DO50075	UCEC	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.3056
p.G2372V	TCGA-AN-A0AK	BRCA	TCGA	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.0556
p.G2372V	DO1608	BRCA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.0556
p.G2372V	DO229245	THCA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.0556
p.P424H	TCGA-AP-A059	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation rewiring degron network	0.3056
p.P424H	DO41361	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation rewiring degron network	0.3056
p.P1891T	TCGA-AP-A059	UCEC	TCGA	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation rewiring degron network	0.0556
p.P1891T	DO41361	UCEC	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation rewiring degron network	0.0556
p.R1864Q	TCGA-AP-A0LM	UCEC	TCGA	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation rewiring degron network	0.0833
p.R1864Q	DO222734	ESCA	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation rewiring degron network	0.0833
p.R1864Q	DO43306	UCEC	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation rewiring degron network	0.0833
p.R1864Q	SIDM01172	Acute Myeloid Leukemia	GDSC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation rewiring degron network	0.0833
p.R1864Q	SIDM01617	Endometrial Carcinoma	GDSC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation rewiring degron network	0.0833
p.R1864Q	THP-1	haematopoietic and lymphoid tissue	COSMIC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation rewiring degron network	0.0833
p.R951H	TCGA-AP-A1DV	UCEC	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation altering degron motif	0.7133
p.R951H	DO43186	UCEC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation altering degron motif	0.7133
p.R601W	TCGA-AX-A1CE	UCEC	TCGA	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation rewiring degron network	0.0833
p.R601W	TCGA-AY-6386	COAD	TCGA	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation rewiring degron network	0.0833
p.R601W	DO9426	COAD	ICGC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation rewiring degron network	0.0833
p.R601W	DO42280	UCEC	ICGC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation rewiring degron network	0.0833
p.K960N	TCGA-AX-A2HC	UCEC	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation substituting flanking lysine	0.2222
p.K960N	DO225261	BRCA	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation substituting flanking lysine	0.2222
p.K960N	DO222481	MELA	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation substituting flanking lysine	0.2222
p.K960N	DO41572	UCEC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation substituting flanking lysine	0.2222
p.S955P	TCGA-AX-A2HD	UCEC	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.25
p.S955P	DO42608	UCEC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.25
p.Q204R	TCGA-B5-A11G	UCEC	TCGA	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.0833
p.Q204R	DO43514	UCEC	ICGC	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.0833
p.S421L	TCGA-B5-A3FA	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation altering degron motif	0.7667
p.S421L	DO52402	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation altering degron motif	0.7667
p.S936P	TCGA-BG-A0MQ	UCEC	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation blocking phosphorylation signal	0.5278
p.S936P	DO41127	UCEC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation blocking phosphorylation signal	0.5278
p.P579L	TCGA-BG-A220	UCEC	TCGA	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation rewiring degron network	0.1111
p.P579L	TCGA-BG-A220	UCEC	TCGA	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.0833
p.P579L	DO41784	UCEC	ICGC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation rewiring degron network	0.1111
p.P579L	DO41784	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.0833
p.G185D	TCGA-BH-A18G	BRCA	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.0833
p.G185D	DO3686	BRCA	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.0833
p.R962H	TCGA-BT-A3PK	BLCA	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.R962H	DO44051	BLCA	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.R962H	SIDM01943	Colorectal Carcinoma	GDSC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.R1874L	TCGA-CC-A7II	LIHC	TCGA	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation altering degron motif	0.8428
p.R1874L	DO52182	LIHC	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation altering degron motif	0.8428
p.K516E	TCGA-CU-A0YO	BLCA	TCGA	PKSTT	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.591
p.K516E	DO466	BLCA	ICGC	PKSTT	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.591
p.P162S	TCGA-CV-6948	HNSC	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.1389
p.P162S	DO14188	HNSC	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.1389
p.P572H	TCGA-CV-6953	HNSC	TCGA	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.2778
p.P572H	DO14278	HNSC	ICGC	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.2778
p.P416T	TCGA-D1-A174	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation rewiring degron network	0.25
p.P416T	DO40900	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation rewiring degron network	0.25
p.K516Q	TCGA-D1-A17L	UCEC	TCGA	PKSTT	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.5833
p.K516Q	DO40847	UCEC	ICGC	PKSTT	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.5833
p.R2287W	TCGA-D1-A17U	UCEC	TCGA	PPPY	ITCH	2292:2295	Mutation rewiring degron network	0.1944
p.R2287W	DO41887	UCEC	ICGC	PPPY	ITCH	2292:2295	Mutation rewiring degron network	0.1944
p.P173H	TCGA-D3-A1Q3	SKCM	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.7694
p.P173H	DO47509	SKCM	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.7694
p.P216S	TCGA-DA-A95Z	SKCM	TCGA	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.6752
p.P216S	DO219481	SKCM	ICGC	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.6752
p.P416L	TCGA-DF-A2KN	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation rewiring degron network	0.25
p.P416L	DO223282	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation rewiring degron network	0.25
p.S1871L	TCGA-DK-AA6S	BLCA	TCGA	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation rewiring degron network	0.2778
p.S1871L	DO219007	BLCA	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation rewiring degron network	0.2778
p.S1871L	DO229054	LICA	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation rewiring degron network	0.2778
p.R179W	TCGA-DU-6392	LGG	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.25
p.R179W	DO22237	LGG	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.25
p.K175N	TCGA-E6-A1LX	UCEC	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.5806
p.K175N	DO41020	UCEC	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.5806
p.P171S	TCGA-EE-A2GI	SKCM	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.5641
p.P171S	DO233867	GACA	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.5641
p.P171S	DO37410	SKCM	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.5641
p.H956N	TCGA-EE-A2MN	SKCM	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.2222
p.H956N	DO37423	SKCM	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.2222
p.E935K	TCGA-EK-A2RD	CESC	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.E935K	DO49946	CESC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.R950Q	TCGA-EY-A215	UCEC	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation altering degron motif	0.6218
p.R950Q	DO42665	UCEC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation altering degron motif	0.6218
p.R2287Q	TCGA-EY-A549	UCEC	TCGA	PPPY	ITCH	2292:2295	Mutation rewiring degron network	0.1944
p.R2287Q	DO48174	UCEC	ICGC	PPPY	ITCH	2292:2295	Mutation rewiring degron network	0.1944
p.V1880A	TCGA-FI-A2D0	UCEC	TCGA	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation altering degron motif	0.6936
p.V1880A	DO43891	UCEC	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation altering degron motif	0.6936
p.P2370S	TCGA-FW-A3R5	SKCM	TCGA	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.1111
p.P2370S	DO37406	SKCM	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.1111
p.Q204K	TCGA-GN-A265	SKCM	TCGA	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.0833
p.Q204K	DO37491	SKCM	ICGC	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.0833
p.T172I	TCGA-GN-A266	SKCM	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.8189
p.T172I	DO37432	SKCM	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.8189
p.R217W	TCGA-KN-8428	KICH	TCGA	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.7523
p.R217W	DO220484	KICH	ICGC	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.7523
p.T172N	TCGA-MH-A562	KIRP	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.8166
p.T172N	DO48495	KIRP	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.8166
p.R962C	TCGA-RY-A843	LGG	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.R962C	DO227657	COCA	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.R962C	DO219843	LGG	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.R962C	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.R962C	ACH-000995	Leukemia	CCLE	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.R962C	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.A514S	TCGA-VS-A9UM	CESC	TCGA	PKSTT	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.A514S	DO51644	CESC	ICGC	PKSTT	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.P574L	TCGA-W3-AA1O	SKCM	TCGA	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.2222
p.P574L	DO51274	SKCM	ICGC	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.2222
p.S2356F	TCGA-Z2-A8RT	SKCM	TCGA	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation altering degron motif	0.6871
p.S2356F	DO222402	MELA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation altering degron motif	0.6871
p.S2356F	DO51301	SKCM	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation altering degron motif	0.6871
p.R525W	DO222427	BTCA	ICGC	PKSTT	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R525W	SIDM00839	Colorectal Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R525W	ACH-000950	Colon/Colorectal Cancer	CCLE	PKSTT	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R525W	LoVo	large intestine	COSMIC	PKSTT	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.S563L	DO229389	BTCA	ICGC	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.S563L	DO37410	SKCM	ICGC	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.S591C	DO52002	CLLE	ICGC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.643
p.R165C	DO230336	COCA	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.2222
p.G958S	DO227549	COCA	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.1667
p.S602P	DO227987	COCA	ICGC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation blocking phosphorylation signal	0.5
p.P1872S	DO227987	COCA	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation rewiring degron network	0.3056
p.D2364G	DO229010	COCA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.2778
p.D2364G	DO229016	COCA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.2778
p.D2364G	DO229005	COCA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.2778
p.D2364G	DO231204	LUSC	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.2778
p.T639P	DO223157	ESCA	ICGC	PATSS	DEG_SPOP_SBC_1	637:641	Mutation altering degron motif	0.7031
p.P629S	DO233272	GACA	ICGC	PATSS	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1111
p.P2370L	DO233693	GACA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.1111
p.G1883D	DO233722	GACA	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation rewiring degron network	0.2778
p.E598G	DO233935	GACA	ICGC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation rewiring degron network	0.1667
p.D2371N	DO229346	LAML	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.0833
p.A170S	DO228986	LICA	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.6477
p.R525L	DO229035	LICA	ICGC	PKSTT	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R585L	DO229038	LICA	ICGC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation rewiring degron network	0.2778
p.P224Q	DO231737	LINC	ICGC	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.1944
p.T176I	DO45057	LINC	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.8189
p.H947R	DO230974	LUSC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation altering degron motif	0.7133
p.H947R	DO224632	LUSC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation altering degron motif	0.7133
p.P584Q	DO220878	MELA	ICGC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation rewiring degron network	0.25
p.S2288F	DO220900	MELA	ICGC	PPPY	ITCH	2292:2295	Mutation blocking phosphorylation signal	0.6667
p.P515S	DO220911	MELA	ICGC	PKSTT	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.6752
p.S1873F	DO222402	MELA	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation altering degron motif	0.6871
p.AH946AY	DO222405	MELA	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	945:952	Mutation altering degron motif	0.7135
p.P495S	DO222638	MELA	ICGC	PPTPTPS	DEG_SCF_FBW7_1	494:500	Mutation altering degron motif	0.5641
p.P2367H	DO232832	NACA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.1944
p.P2360Q	DO233296	NACA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation altering degron motif	0.5924
p.S2356A	DO46483	OV	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation altering degron motif	0.6477
p.E2346Q	DO29760	OV	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation rewiring degron network	0.1111
p.T578M	DO220258	SARC	ICGC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation rewiring degron network	0.0833
p.T578M	DO220258	SARC	ICGC	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1111
p.P581S	DO229446	SKCA	ICGC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation rewiring degron network	0.1667
p.L417P	DO229140	THCA	ICGC	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation rewiring degron network	0.2778
p.L417P	DO229092	THCA	ICGC	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation rewiring degron network	0.2778
p.S632P	DO229148	THCA	ICGC	PATSS	DEG_SPOP_SBC_1	637:641	Mutation blocking phosphorylation signal	0.6389
p.P432Q	DO229221	THCA	ICGC	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation rewiring degron network	0.0833
p.C560Y	DO42033	UCEC	ICGC	PITTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1667
p.R1874W	SIDM02013	Colorectal Carcinoma	GDSC	SRRPLGGVS	DEG_APCC_DBOX_1	1873:1881	Mutation altering degron motif	0.8634
p.P206T	SIDM00373	Endometrial Carcinoma	GDSC	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.1389
p.P206T	ACH-000974	Endometrial/Uterine Cancer	CCLE	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.1389
p.P206T	SNG-M	endometrium	COSMIC	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.1389
p.P587R	SIDM01151	Hepatocellular Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM00535	Chondrosarcoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM00530	Esophageal Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM00260	Gastric Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM00556	Neuroblastoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM00821	Kidney Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM00299	Other Sarcomas	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM00276	Biliary Tract Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM00609	Kidney Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM00469	Pancreatic Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM00381	Cervical Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM01608	Endometrial Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM01470	Acute Myeloid Leukemia	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM01578	Bladder Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM00248	Gastric Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM01378	Ovarian Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.P587R	SIDM01434	Hepatocellular Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7512
p.G491S	SIDM00855	Other Sarcomas	GDSC	PPTPTPS	DEG_SCF_FBW7_1	494:500	Mutation rewiring degron network	0.25
p.G491S	SIDM00785	Acute Myeloid Leukemia	GDSC	PPTPTPS	DEG_SCF_FBW7_1	494:500	Mutation rewiring degron network	0.25
p.P174A	SIDM00594	Acute Myeloid Leukemia	GDSC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.6392
p.P174A	HEL	haematopoietic and lymphoid tissue	COSMIC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.6392
p.P174A	CMK	haematopoietic and lymphoid tissue	COSMIC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.6392
p.R226W	SIDM00789	Colorectal Carcinoma	GDSC	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.1389
p.R226W	ACH-000997	Colon/Colorectal Cancer	CCLE	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation rewiring degron network	0.1389
p.R2355W	SIDM00846	Cervical Carcinoma	GDSC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation altering degron motif	0.8634
p.E2354K	SIDM00735	Small Cell Lung Carcinoma	GDSC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation altering degron motif	0.591
p.E2354K	NCI-H2029	lung	COSMIC	ERSPLLPLP	DEG_APCC_DBOX_1	2354:2362	Mutation altering degron motif	0.591
p.R218P	SIDM00181	Bladder Carcinoma	GDSC	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.6401
p.R218P	ACH-002266	Bladder Cancer	CCLE	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.6401
p.R218P	LB831-BLC	urinary tract	COSMIC	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.6401
p.P587S	SIDM00898	Breast Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.6752
p.P587S	ACH-000248	Breast Cancer	CCLE	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.6752
p.P587S	AU565	breast	COSMIC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.6752
p.P631S	SIDM01066	Melanoma	GDSC	PATSS	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1667
p.P631S	ACH-000650	Skin Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	637:641	Mutation rewiring degron network	0.1667
p.P216R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.7512
p.P216R	NCI-H23	lung	COSMIC	PSTPRRS	DEG_SCF_FBW7_1	213:219	Mutation altering degron motif	0.7512
p.P2289L	SIDM00816	Kidney Carcinoma	GDSC	PPPY	ITCH	2292:2295	Mutation rewiring degron network	0.25
p.P2289L	RCC-MF	kidney	COSMIC	PPPY	ITCH	2292:2295	Mutation rewiring degron network	0.25
p.T592N	SIDM00980	Gastric Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7055
p.T592N	ACH-000948	Gastric Cancer	CCLE	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7055
p.T592N	23132-87	stomach	COSMIC	PTPPST	DEG_SCF_FBW7_1	587:592	Mutation altering degron motif	0.7055
p.R165H	SIDM01617	Endometrial Carcinoma	GDSC	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.2222
p.R165H	ACH-000994	Endometrial/Uterine Cancer	CCLE	VAPTPPKT	DEG_SCF_FBW7_1	169:176	Mutation rewiring degron network	0.2222
p.A2297T	ACH-000285	Lymphoma	CCLE	PPPY	ITCH	2292:2295	Mutation rewiring degron network	0.2778
p.A2297D	ACH-000285	Lymphoma	CCLE	PPPY	ITCH	2292:2295	Mutation rewiring degron network	0.2778
p.G2286C	ACH-000592	Brain Cancer	CCLE	PPPY	ITCH	2292:2295	Mutation rewiring degron network	0.1667
p.P427T	ACH-001610	Brain Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	419:423	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KMT2B

UniProt ID: Q9UMN6

Entrez ID: 9757

Protein name: Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KMT2B in