DegronMD

Uniprot ID: Q9UMN6

Source protein: Histone-lysine N-methyltransferase 2B

Source gene: KMT2B

Class: DEG_SCF_FBW7_1

Location: 213:219

E3 ligase: FBXW7

DEGRON score: 0.8885

ASA_SCORE: 113.9

COIL: 0.9569

CONS_SCORE: 0.3063

DSS_SCORE: 0.797

HELIX: 0.0154

FCONS_SCORE: 0.9267

RIG_SCORE: 0.5618

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q204R	TCGA-B5-A11G	UCEC	TCGA	PSTPRRS	DEG_SCF_FBW7_1	0.0833
p.Q204R	DO43514	UCEC	ICGC	PSTPRRS	DEG_SCF_FBW7_1	0.0833
p.P216S	TCGA-DA-A95Z	SKCM	TCGA	PSTPRRS	DEG_SCF_FBW7_1	0.6752
p.P216S	DO219481	SKCM	ICGC	PSTPRRS	DEG_SCF_FBW7_1	0.6752
p.Q204K	TCGA-GN-A265	SKCM	TCGA	PSTPRRS	DEG_SCF_FBW7_1	0.0833
p.Q204K	DO37491	SKCM	ICGC	PSTPRRS	DEG_SCF_FBW7_1	0.0833
p.R217W	TCGA-KN-8428	KICH	TCGA	PSTPRRS	DEG_SCF_FBW7_1	0.7523
p.R217W	DO220484	KICH	ICGC	PSTPRRS	DEG_SCF_FBW7_1	0.7523
p.P224Q	DO231737	LINC	ICGC	PSTPRRS	DEG_SCF_FBW7_1	0.1944
p.P206T	SIDM00373	Endometrial Carcinoma	GDSC	PSTPRRS	DEG_SCF_FBW7_1	0.1389
p.P206T	ACH-000974	Endometrial/Uterine Cancer	CCLE	PSTPRRS	DEG_SCF_FBW7_1	0.1389
p.P206T	SNG-M	endometrium	COSMIC	PSTPRRS	DEG_SCF_FBW7_1	0.1389
p.R226W	SIDM00789	Colorectal Carcinoma	GDSC	PSTPRRS	DEG_SCF_FBW7_1	0.1389
p.R226W	ACH-000997	Colon/Colorectal Cancer	CCLE	PSTPRRS	DEG_SCF_FBW7_1	0.1389
p.R218P	SIDM00181	Bladder Carcinoma	GDSC	PSTPRRS	DEG_SCF_FBW7_1	0.6401
p.R218P	ACH-002266	Bladder Cancer	CCLE	PSTPRRS	DEG_SCF_FBW7_1	0.6401
p.R218P	LB831-BLC	urinary_tract	COSMIC	PSTPRRS	DEG_SCF_FBW7_1	0.6401
p.P216R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PSTPRRS	DEG_SCF_FBW7_1	0.7512
p.P216R	NCI-H23	lung	COSMIC	PSTPRRS	DEG_SCF_FBW7_1	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SCF_FBW7_1	213:219	PSTPRRS	FBXW7	0.8885	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons