DegronMD

Uniprot ID: Q9UMN6

Source protein: Histone-lysine N-methyltransferase 2B

Source gene: KMT2B

Class: DEG_SCF_FBW7_1

Location: 945:952

E3 ligase: FBXW7

DEGRON score: 0.8584

ASA_SCORE: 100.25

COIL: 0.87

CONS_SCORE: 0.3686

DSS_SCORE: 0.736

HELIX: 0.0289

FCONS_SCORE: 0.8915

RIG_SCORE: 0.6308

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S955Y	TCGA-62-8399	LUAD	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	0.25
p.S955Y	DO24606	LUAD	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.25
p.K959N	TCGA-AA-A010	COAD	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	0.25
p.R951H	TCGA-AP-A1DV	UCEC	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	0.7133
p.R951H	DO43186	UCEC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.7133
p.K960N	TCGA-AX-A2HC	UCEC	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	0.2222
p.K960N	DO225261	BRCA	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.2222
p.K960N	DO222481	MELA	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.2222
p.K960N	DO41572	UCEC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.2222
p.S955P	TCGA-AX-A2HD	UCEC	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	0.25
p.S955P	DO42608	UCEC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.25
p.S936P	TCGA-BG-A0MQ	UCEC	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	0.5278
p.S936P	DO41127	UCEC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.5278
p.R962H	TCGA-BT-A3PK	BLCA	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	0.0556
p.R962H	DO44051	BLCA	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.0556
p.R962H	SIDM01943	Colorectal Carcinoma	GDSC	LAHTPRRS	DEG_SCF_FBW7_1	0.0556
p.H956N	TCGA-EE-A2MN	SKCM	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	0.2222
p.H956N	DO37423	SKCM	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.2222
p.E935K	TCGA-EK-A2RD	CESC	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	0.0556
p.E935K	DO49946	CESC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.0556
p.R950Q	TCGA-EY-A215	UCEC	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	0.6218
p.R950Q	DO42665	UCEC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.6218
p.R962C	TCGA-RY-A843	LGG	TCGA	LAHTPRRS	DEG_SCF_FBW7_1	0.0556
p.R962C	DO227657	COCA	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.0556
p.R962C	DO219843	LGG	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.0556
p.R962C	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LAHTPRRS	DEG_SCF_FBW7_1	0.0556
p.R962C	ACH-000995	Leukemia	CCLE	LAHTPRRS	DEG_SCF_FBW7_1	0.0556
p.R962C	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LAHTPRRS	DEG_SCF_FBW7_1	0.0556
p.G958S	DO227549	COCA	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.1667
p.H947R	DO230974	LUSC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.7133
p.H947R	DO224632	LUSC	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.7133
p.AH946AY	DO222405	MELA	ICGC	LAHTPRRS	DEG_SCF_FBW7_1	0.7135

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAHTPRRS

Degron related mutations and impact score

Drug responses associated with KMT2B mutations

All proteins holding degron of LAHTPRRS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SCF_FBW7_1	945:952	LAHTPRRS	FBXW7	0.8584	More...