DegronMD

Uniprot ID: Q9UMN6

Source protein: Histone-lysine N-methyltransferase 2B

Source gene: KMT2B

Class: DEG_SCF_FBW7_1

Location: 169:176

E3 ligase: FBXW7

DEGRON score: 0.9866

ASA_SCORE: 92.125

COIL: 0.9701

CONS_SCORE: 0.3039

DSS_SCORE: 0.8339

HELIX: 0.0106

FCONS_SCORE: 0.9934

RIG_SCORE: 0.6031

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R179L	TCGA-39-5034	LUSC	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	0.25
p.R179L	DO26854	LUSC	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.25
p.P160H	TCGA-41-2575	GBM	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	0.0833
p.P160H	DO10874	GBM	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.0833
p.R181W	TCGA-AA-3492	COAD	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	0.1944
p.R181W	DO8224	COAD	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.1944
p.R181W	DO233737	GACA	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.1944
p.D168Y	TCGA-AJ-A5DW	UCEC	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	0.3056
p.D168Y	DO50075	UCEC	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.3056
p.G185D	TCGA-BH-A18G	BRCA	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	0.0833
p.G185D	DO3686	BRCA	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.0833
p.P162S	TCGA-CV-6948	HNSC	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	0.1389
p.P162S	DO14188	HNSC	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.1389
p.P173H	TCGA-D3-A1Q3	SKCM	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	0.7694
p.P173H	DO47509	SKCM	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.7694
p.R179W	TCGA-DU-6392	LGG	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	0.25
p.R179W	DO22237	LGG	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.25
p.K175N	TCGA-E6-A1LX	UCEC	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	0.5806
p.K175N	DO41020	UCEC	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.5806
p.P171S	TCGA-EE-A2GI	SKCM	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	0.5641
p.P171S	DO233867	GACA	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.5641
p.P171S	DO37410	SKCM	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.5641
p.T172I	TCGA-GN-A266	SKCM	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	0.8189
p.T172I	DO37432	SKCM	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.8189
p.T172N	TCGA-MH-A562	KIRP	TCGA	VAPTPPKT	DEG_SCF_FBW7_1	0.8166
p.T172N	DO48495	KIRP	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.8166
p.R165C	DO230336	COCA	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.2222
p.A170S	DO228986	LICA	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.6477
p.T176I	DO45057	LINC	ICGC	VAPTPPKT	DEG_SCF_FBW7_1	0.8189
p.P174A	SIDM00594	Acute Myeloid Leukemia	GDSC	VAPTPPKT	DEG_SCF_FBW7_1	0.6392
p.P174A	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	VAPTPPKT	DEG_SCF_FBW7_1	0.6392
p.P174A	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	VAPTPPKT	DEG_SCF_FBW7_1	0.6392
p.R165H	SIDM01617	Endometrial Carcinoma	GDSC	VAPTPPKT	DEG_SCF_FBW7_1	0.2222
p.R165H	ACH-000994	Endometrial/Uterine Cancer	CCLE	VAPTPPKT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VAPTPPKT

Degron related mutations and impact score

Drug responses associated with KMT2B mutations

All proteins holding degron of VAPTPPKT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SCF_FBW7_1	169:176	VAPTPPKT	FBXW7	0.9866	More...