DegronMD

Uniprot ID: Q9UMN6

Source protein: Histone-lysine N-methyltransferase 2B

Source gene: KMT2B

Class: DEG_APCC_DBOX_1

Location: 1873:1881

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9085

ASA_SCORE: 85.3222

COIL: 0.9469

CONS_SCORE: 0.3562

DSS_SCORE: 0.5596

HELIX: 0.0156

FCONS_SCORE: 1.0606

RIG_SCORE: 0.6057

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1891T	TCGA-AP-A059	UCEC	TCGA	SRRPLGGVS	DEG_APCC_DBOX_1	0.0556
p.P1891T	DO41361	UCEC	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	0.0556
p.R1864Q	TCGA-AP-A0LM	UCEC	TCGA	SRRPLGGVS	DEG_APCC_DBOX_1	0.0833
p.R1864Q	DO222734	ESCA	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	0.0833
p.R1864Q	DO43306	UCEC	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	0.0833
p.R1864Q	SIDM01172	Acute Myeloid Leukemia	GDSC	SRRPLGGVS	DEG_APCC_DBOX_1	0.0833
p.R1864Q	SIDM01617	Endometrial Carcinoma	GDSC	SRRPLGGVS	DEG_APCC_DBOX_1	0.0833
p.R1864Q	THP-1	haematopoietic_and_lymphoid_tissue	COSMIC	SRRPLGGVS	DEG_APCC_DBOX_1	0.0833
p.R1874L	TCGA-CC-A7II	LIHC	TCGA	SRRPLGGVS	DEG_APCC_DBOX_1	0.8428
p.R1874L	DO52182	LIHC	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	0.8428
p.S1871L	TCGA-DK-AA6S	BLCA	TCGA	SRRPLGGVS	DEG_APCC_DBOX_1	0.2778
p.S1871L	DO219007	BLCA	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	0.2778
p.S1871L	DO229054	LICA	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	0.2778
p.V1880A	TCGA-FI-A2D0	UCEC	TCGA	SRRPLGGVS	DEG_APCC_DBOX_1	0.6936
p.V1880A	DO43891	UCEC	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	0.6936
p.P1872S	DO227987	COCA	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	0.3056
p.G1883D	DO233722	GACA	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	0.2778
p.S1873F	DO222402	MELA	ICGC	SRRPLGGVS	DEG_APCC_DBOX_1	0.6871
p.R1874W	SIDM02013	Colorectal Carcinoma	GDSC	SRRPLGGVS	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_APCC_DBOX_1	1873:1881	SRRPLGGVS	APC,CDC20,FZR1	0.9085	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons