DegronMD

Uniprot ID: Q9UMN6

Source protein: Histone-lysine N-methyltransferase 2B

Source gene: KMT2B

Class: DEG_SCF_FBW7_1

Location: 587:592

E3 ligase: FBXW7

DEGRON score: 0.6886

ASA_SCORE: 92.8167

COIL: 0.9722

CONS_SCORE: 0.3351

DSS_SCORE: 0.7187

HELIX: 0.0093

FCONS_SCORE: 0.9478

RIG_SCORE: 0.5162

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R601W	TCGA-AX-A1CE	UCEC	TCGA	PTPPST	DEG_SCF_FBW7_1	0.0833
p.R601W	TCGA-AY-6386	COAD	TCGA	PTPPST	DEG_SCF_FBW7_1	0.0833
p.R601W	DO9426	COAD	ICGC	PTPPST	DEG_SCF_FBW7_1	0.0833
p.R601W	DO42280	UCEC	ICGC	PTPPST	DEG_SCF_FBW7_1	0.0833
p.P579L	TCGA-BG-A220	UCEC	TCGA	PTPPST	DEG_SCF_FBW7_1	0.1111
p.P579L	DO41784	UCEC	ICGC	PTPPST	DEG_SCF_FBW7_1	0.1111
p.S591C	DO52002	CLLE	ICGC	PTPPST	DEG_SCF_FBW7_1	0.643
p.S602P	DO227987	COCA	ICGC	PTPPST	DEG_SCF_FBW7_1	0.5
p.E598G	DO233935	GACA	ICGC	PTPPST	DEG_SCF_FBW7_1	0.1667
p.R585L	DO229038	LICA	ICGC	PTPPST	DEG_SCF_FBW7_1	0.2778
p.P584Q	DO220878	MELA	ICGC	PTPPST	DEG_SCF_FBW7_1	0.25
p.T578M	DO220258	SARC	ICGC	PTPPST	DEG_SCF_FBW7_1	0.0833
p.P581S	DO229446	SKCA	ICGC	PTPPST	DEG_SCF_FBW7_1	0.1667
p.P587R	SIDM01151	Hepatocellular Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM00535	Chondrosarcoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM00530	Esophageal Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM00260	Gastric Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM00556	Neuroblastoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM00821	Kidney Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM00299	Other Sarcomas	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM00276	Biliary Tract Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM00609	Kidney Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM00469	Pancreatic Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM00381	Cervical Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM01608	Endometrial Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM01470	Acute Myeloid Leukemia	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM01578	Bladder Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM00248	Gastric Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM01378	Ovarian Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587R	SIDM01434	Hepatocellular Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7512
p.P587S	SIDM00898	Breast Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.6752
p.P587S	ACH-000248	Breast Cancer	CCLE	PTPPST	DEG_SCF_FBW7_1	0.6752
p.P587S	AU565	breast	COSMIC	PTPPST	DEG_SCF_FBW7_1	0.6752
p.T592N	SIDM00980	Gastric Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.7055
p.T592N	ACH-000948	Gastric Cancer	CCLE	PTPPST	DEG_SCF_FBW7_1	0.7055
p.T592N	23132-87	stomach	COSMIC	PTPPST	DEG_SCF_FBW7_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35227	Polycomb group RING finger protein 2	DEG_SCF_FBW7_1	300:305	PTPPST	FBXW7	0.9067	More...
Q68EM7	Rho GTPase-activating protein 17	DEG_SCF_FBW7_1	758:763	PTPPST	FBXW7	0.9967	More...
Q7Z7A4	PX domain-containing protein kinase-like protein	DEG_SCF_FBW7_1	503:508	PTPPST	FBXW7	0.9915	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SCF_FBW7_1	587:592	PTPPST	FBXW7	0.6886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPPST

Degron related mutations and impact score

Drug responses associated with KMT2B mutations

All proteins holding degron of PTPPST