DegronMD - Q68EM7(ARHGAP17)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S551R	TCGA-36-2534	OV	TCGA	AESSS	DEG_SPOP_SBC_1	549:553	Mutation altering degron motif	0.7427
p.S551R	DO29046	OV	ICGC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation altering degron motif	0.7427
p.P542L	TCGA-55-8507	LUAD	TCGA	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1389
p.P542L	DO45412	LUAD	ICGC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1389
p.T759M	TCGA-A5-A0G2	UCEC	TCGA	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation altering degron motif	0.8534
p.T759M	DO41235	UCEC	ICGC	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation altering degron motif	0.8534
p.T759M	SIDM00359	Colorectal Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation altering degron motif	0.8534
p.T759M	ACH-000565	Colon/Colorectal Cancer	CCLE	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation altering degron motif	0.8534
p.T759M	RCM-1	large intestine	COSMIC	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation altering degron motif	0.8534
p.S561F	TCGA-AN-A0FL	BRCA	TCGA	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1111
p.S561F	DO1836	BRCA	ICGC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1111
p.A562T	TCGA-AX-A1CE	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0833
p.A562T	DO42280	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0833
p.G767V	TCGA-B5-A0JY	UCEC	TCGA	PSHTPPQT	DEG_SCF_FBW7_1	750:757	Mutation rewiring degron network	0.0556
p.G767V	TCGA-B5-A0JY	UCEC	TCGA	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation rewiring degron network	0.2222
p.G767V	DO43041	UCEC	ICGC	PSHTPPQT	DEG_SCF_FBW7_1	750:757	Mutation rewiring degron network	0.0556
p.G767V	DO43041	UCEC	ICGC	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation rewiring degron network	0.2222
p.S553F	TCGA-CR-6481	HNSC	TCGA	AESSS	DEG_SPOP_SBC_1	549:553	Mutation altering degron motif	0.7982
p.S553F	DO14990	HNSC	ICGC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation altering degron motif	0.7982
p.L766P	TCGA-IB-A5SQ	PAAD	TCGA	PSHTPPQT	DEG_SCF_FBW7_1	750:757	Mutation rewiring degron network	0.0833
p.L766P	TCGA-IB-A5SQ	PAAD	TCGA	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation rewiring degron network	0.25
p.L766P	DO46653	PAAD	ICGC	PSHTPPQT	DEG_SCF_FBW7_1	750:757	Mutation rewiring degron network	0.0833
p.L766P	DO46653	PAAD	ICGC	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation rewiring degron network	0.25
p.P540L	TCGA-MT-A67D	HNSC	TCGA	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0833
p.P540L	DO49064	HNSC	ICGC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0833
p.G539S	TCGA-NC-A5HI	LUSC	TCGA	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0556
p.G539S	DO45461	LUSC	ICGC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0556
p.P764L	DO233693	GACA	ICGC	PSHTPPQT	DEG_SCF_FBW7_1	750:757	Mutation rewiring degron network	0.1389
p.P764L	DO233693	GACA	ICGC	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation rewiring degron network	0.3056
p.P742T	DO229035	LICA	ICGC	PSHTPPQT	DEG_SCF_FBW7_1	750:757	Mutation rewiring degron network	0.1111
p.L747I	DO229008	LICA	ICGC	PSHTPPQT	DEG_SCF_FBW7_1	750:757	Mutation rewiring degron network	0.25
p.P543S	DO222390	MELA	ICGC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1667
p.S751A	DO229487	PRAD	ICGC	PSHTPPQT	DEG_SCF_FBW7_1	750:757	Mutation altering degron motif	0.7588
p.S772R	SIDM00689	B-Lymphoblastic Leukemia	GDSC	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation rewiring degron network	0.0833
p.S772R	ACH-000151	Leukemia	CCLE	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation rewiring degron network	0.0833
p.S772R	JM1	haematopoietic and lymphoid tissue	COSMIC	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation rewiring degron network	0.0833
p.A562V	SIDM00435	Acute Myeloid Leukemia	GDSC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0833
p.A562V	SIDM00617	Hepatocellular Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0833
p.A562V	SIDM00352	Ovarian Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0833
p.A562V	SIDM00860	Head and Neck Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0833
p.A562V	SIDM00274	Gastric Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0833
p.A562V	SIDM01609	Endometrial Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0833
p.A562V	SIDM00062	Hepatocellular Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0833
p.P771H	SIDM00214	Colorectal Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation rewiring degron network	0.1111
p.P771H	ACH-000955	Colon/Colorectal Cancer	CCLE	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation rewiring degron network	0.1111
p.P771H	SNU-407	large intestine	COSMIC	PTPPST	DEG_SCF_FBW7_1	758:763	Mutation rewiring degron network	0.1111
p.R552H	SNU-C5	large intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation altering degron motif	0.8244
p.V555I	NCI-H720	lung	COSMIC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.2778
p.A561S	SNU-1040	large intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1111
p.N750T	Hs683	central nervous system	COSMIC	PSHTPPQT	DEG_SCF_FBW7_1	750:757	Mutation altering degron motif	0.7055

Kaplan plot for ARHGAP17 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP17

UniProt ID: Q68EM7

Entrez ID: 55114

Protein name: Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP17 in