DegronMD

Uniprot ID: Q68EM7

Source protein: Rho GTPase-activating protein 17

Source gene: ARHGAP17

Class: DEG_SCF_FBW7_1

Location: 750:757

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 99.8375

COIL: 0.9664

CONS_SCORE: 0.4041

DSS_SCORE: 0.9394

HELIX: 0.0098

FCONS_SCORE: 1.0624

RIG_SCORE: 0.455

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G767V	TCGA-B5-A0JY	UCEC	TCGA	PSHTPPQT	DEG_SCF_FBW7_1	0.0556
p.G767V	DO43041	UCEC	ICGC	PSHTPPQT	DEG_SCF_FBW7_1	0.0556
p.L766P	TCGA-IB-A5SQ	PAAD	TCGA	PSHTPPQT	DEG_SCF_FBW7_1	0.0833
p.L766P	DO46653	PAAD	ICGC	PSHTPPQT	DEG_SCF_FBW7_1	0.0833
p.P764L	DO233693	GACA	ICGC	PSHTPPQT	DEG_SCF_FBW7_1	0.1389
p.P742T	DO229035	LICA	ICGC	PSHTPPQT	DEG_SCF_FBW7_1	0.1111
p.L747I	DO229008	LICA	ICGC	PSHTPPQT	DEG_SCF_FBW7_1	0.25
p.S751A	DO229487	PRAD	ICGC	PSHTPPQT	DEG_SCF_FBW7_1	0.7588
p.N750T	Hs683	central_nervous_system	COSMIC	PSHTPPQT	DEG_SCF_FBW7_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68EM7	Rho GTPase-activating protein 17	DEG_SCF_FBW7_1	750:757	PSHTPPQT	FBXW7	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons