DegronMD

Uniprot ID: Q68EM7

Source protein: Rho GTPase-activating protein 17

Source gene: ARHGAP17

Class: DEG_SCF_FBW7_1

Location: 758:763

E3 ligase: FBXW7

DEGRON score: 0.9967

ASA_SCORE: 89.5167

COIL: 0.9788

CONS_SCORE: 0.4128

DSS_SCORE: 0.9309

HELIX: 0.0073

FCONS_SCORE: 1.1286

RIG_SCORE: 0.4879

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T759M	TCGA-A5-A0G2	UCEC	TCGA	PTPPST	DEG_SCF_FBW7_1	0.8534
p.T759M	DO41235	UCEC	ICGC	PTPPST	DEG_SCF_FBW7_1	0.8534
p.T759M	SIDM00359	Colorectal Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.8534
p.T759M	ACH-000565	Colon/Colorectal Cancer	CCLE	PTPPST	DEG_SCF_FBW7_1	0.8534
p.T759M	RCM-1	large_intestine	COSMIC	PTPPST	DEG_SCF_FBW7_1	0.8534
p.G767V	TCGA-B5-A0JY	UCEC	TCGA	PTPPST	DEG_SCF_FBW7_1	0.2222
p.G767V	DO43041	UCEC	ICGC	PTPPST	DEG_SCF_FBW7_1	0.2222
p.L766P	TCGA-IB-A5SQ	PAAD	TCGA	PTPPST	DEG_SCF_FBW7_1	0.25
p.L766P	DO46653	PAAD	ICGC	PTPPST	DEG_SCF_FBW7_1	0.25
p.P764L	DO233693	GACA	ICGC	PTPPST	DEG_SCF_FBW7_1	0.3056
p.S772R	SIDM00689	B-Lymphoblastic Leukemia	GDSC	PTPPST	DEG_SCF_FBW7_1	0.0833
p.S772R	ACH-000151	Leukemia	CCLE	PTPPST	DEG_SCF_FBW7_1	0.0833
p.S772R	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPST	DEG_SCF_FBW7_1	0.0833
p.P771H	SIDM00214	Colorectal Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.1111
p.P771H	ACH-000955	Colon/Colorectal Cancer	CCLE	PTPPST	DEG_SCF_FBW7_1	0.1111
p.P771H	SNU-407	large_intestine	COSMIC	PTPPST	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35227	Polycomb group RING finger protein 2	DEG_SCF_FBW7_1	300:305	PTPPST	FBXW7	0.9067	More...
Q68EM7	Rho GTPase-activating protein 17	DEG_SCF_FBW7_1	758:763	PTPPST	FBXW7	0.9967	More...
Q7Z7A4	PX domain-containing protein kinase-like protein	DEG_SCF_FBW7_1	503:508	PTPPST	FBXW7	0.9915	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SCF_FBW7_1	587:592	PTPPST	FBXW7	0.6886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons