DegronMD

Uniprot ID: Q7Z7A4

Source protein: PX domain-containing protein kinase-like protein

Source gene: PXK

Class: DEG_SCF_FBW7_1

Location: 503:508

E3 ligase: FBXW7

DEGRON score: 0.9915

ASA_SCORE: 91.4333

COIL: 0.9705

CONS_SCORE: 0.4245

DSS_SCORE: 0.7264

HELIX: 0.0137

FCONS_SCORE: 1.1525

RIG_SCORE: 0.43

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S494N	TCGA-BH-A0DE	BRCA	TCGA	PTPPST	DEG_SCF_FBW7_1	0.0833
p.S494N	DO2688	BRCA	ICGC	PTPPST	DEG_SCF_FBW7_1	0.0833
p.P506L	TCGA-EE-A29X	SKCM	TCGA	PTPPST	DEG_SCF_FBW7_1	0.6471
p.G495V	DO228948	LICA	ICGC	PTPPST	DEG_SCF_FBW7_1	0.1111
p.S497I	DO229032	LICA	ICGC	PTPPST	DEG_SCF_FBW7_1	0.1667
p.V510L	DO229037	LICA	ICGC	PTPPST	DEG_SCF_FBW7_1	0.2778
p.A493S	DO229037	LICA	ICGC	PTPPST	DEG_SCF_FBW7_1	0.0556
p.T508A	DO23290	LINC	ICGC	PTPPST	DEG_SCF_FBW7_1	0.7139
p.S512P	DO219174	LUSC	ICGC	PTPPST	DEG_SCF_FBW7_1	0.2222
p.R499I	DO50075	UCEC	ICGC	PTPPST	DEG_SCF_FBW7_1	0.2222
p.S499C	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.2222
p.S499C	ACH-000611	Lymphoma	CCLE	PTPPST	DEG_SCF_FBW7_1	0.2222
p.S499C	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPST	DEG_SCF_FBW7_1	0.2222
p.P506H	HCT-15	large_intestine	COSMIC	PTPPST	DEG_SCF_FBW7_1	0.6583

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35227	Polycomb group RING finger protein 2	DEG_SCF_FBW7_1	300:305	PTPPST	FBXW7	0.9067	More...
Q68EM7	Rho GTPase-activating protein 17	DEG_SCF_FBW7_1	758:763	PTPPST	FBXW7	0.9967	More...
Q7Z7A4	PX domain-containing protein kinase-like protein	DEG_SCF_FBW7_1	503:508	PTPPST	FBXW7	0.9915	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SCF_FBW7_1	587:592	PTPPST	FBXW7	0.6886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons