DegronMD

Uniprot ID: P35227

Source protein: Polycomb group RING finger protein 2

Source gene: PCGF2

Class: DEG_SCF_FBW7_1

Location: 300:305

E3 ligase: FBXW7

DEGRON score: 0.9067

ASA_SCORE: 95.3667

COIL: 0.9647

CONS_SCORE: 0.3667

DSS_SCORE: 0.7624

HELIX: 0.0217

FCONS_SCORE: 0.9826

RIG_SCORE: 0.5145

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T298P	DO46468	OV	ICGC	PTPPST	DEG_SCF_FBW7_1	0.2778
p.H296P	DO218888	SKCA	ICGC	PTPPST	DEG_SCF_FBW7_1	0.2222
p.T295S	DO222769	COCA	ICGC	PTPPST	DEG_SCF_FBW7_1	0.1944
p.A294P	ACH-001610	Brain Cancer	CCLE	PTPPST	DEG_SCF_FBW7_1	0.1667
p.A313V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	0.1111

Showing 1 to 5 of 5 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SCF_FBW7_1	587:592	PTPPST	FBXW7	0.6886	More...
P35227	Polycomb group RING finger protein 2	DEG_SCF_FBW7_1	300:305	PTPPST	FBXW7	0.9067	More...
Q7Z7A4	PX domain-containing protein kinase-like protein	DEG_SCF_FBW7_1	503:508	PTPPST	FBXW7	0.9915	More...
Q68EM7	Rho GTPase-activating protein 17	DEG_SCF_FBW7_1	758:763	PTPPST	FBXW7	0.9967	More...

Showing 1 to 4 of 4 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons