DegronMD - P35227(PCGF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A271P	TCGA-42-2589	OV	TCGA	PATSS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.6392
p.A271P	DO31130	OV	ICGC	PATSS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.6392
p.K332N	TCGA-AJ-A3EL	UCEC	TCGA	LQTPSST	DEG_SCF_FBW7_1	321:327	Mutation substituting flanking lysine	0.3056
p.K332N	TCGA-AJ-A3EL	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	324:328	Mutation substituting flanking lysine	0.3333
p.K332N	DO233749	GACA	ICGC	LQTPSST	DEG_SCF_FBW7_1	321:327	Mutation substituting flanking lysine	0.3056
p.K332N	DO233749	GACA	ICGC	PSSTS	DEG_SPOP_SBC_1	324:328	Mutation substituting flanking lysine	0.3333
p.K332N	DO41542	UCEC	ICGC	LQTPSST	DEG_SCF_FBW7_1	321:327	Mutation substituting flanking lysine	0.3056
p.K332N	DO41542	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	324:328	Mutation substituting flanking lysine	0.3333
p.A271V	TCGA-AX-A1CE	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.5825
p.A271V	DO42280	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.5825
p.D261N	TCGA-AX-A2HC	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.0833
p.D261N	TCGA-BR-8078	STAD	TCGA	PATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.0833
p.D261N	DO38288	STAD	ICGC	PATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.0833
p.D261N	DO41572	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.0833
p.D261N	ACH-000989	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.0833
p.S278N	TCGA-AX-A2HD	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.2222
p.S278N	DO42608	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.2222
p.P264S	TCGA-CK-4951	COAD	TCGA	PATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1667
p.P264S	DO10582	COAD	ICGC	PATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1667
p.P270L	TCGA-DD-A1EL	LIHC	TCGA	PATSS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.7582
p.P270L	DO23048	LIHC	ICGC	PATSS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.7582
p.A271T	TCGA-DF-A2KN	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.6028
p.A271T	DO223282	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.6028
p.T295S	DO222769	COCA	ICGC	PTPPST	DEG_SCF_FBW7_1	300:305	Mutation rewiring degron network	0.1944
p.S328N	DO233935	GACA	ICGC	PSSTS	DEG_SPOP_SBC_1	324:328	Mutation altering degron motif	0.7069
p.A239V	DO231722	LINC	ICGC	KRLTLATVP	DEG_APCC_DBOX_1	234:242	Mutation altering degron motif	0.5825
p.P244L	DO230522	LUSC	ICGC	KRLTLATVP	DEG_APCC_DBOX_1	234:242	Mutation rewiring degron network	0.2778
p.T298P	DO46468	OV	ICGC	PTPPST	DEG_SCF_FBW7_1	300:305	Mutation rewiring degron network	0.2778
p.H296P	DO218888	SKCA	ICGC	PTPPST	DEG_SCF_FBW7_1	300:305	Mutation rewiring degron network	0.2222
p.P324Q	SIDM00193	Colorectal Carcinoma	GDSC	LQTPSST	DEG_SCF_FBW7_1	321:327	Mutation altering degron motif	0.7035
p.P324Q	SIDM00193	Colorectal Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	324:328	Mutation altering degron motif	0.7035
p.P324Q	ACH-000991	Colon/Colorectal Cancer	CCLE	LQTPSST	DEG_SCF_FBW7_1	321:327	Mutation altering degron motif	0.7035
p.P324Q	ACH-000991	Colon/Colorectal Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	324:328	Mutation altering degron motif	0.7035
p.A313V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PTPPST	DEG_SCF_FBW7_1	300:305	Mutation rewiring degron network	0.1111
p.A313V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LQTPSST	DEG_SCF_FBW7_1	321:327	Mutation rewiring degron network	0.1111
p.T281P	ACH-000415	Head and Neck Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1389
p.K262R	ACH-000650	Skin Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	270:274	Mutation substituting flanking lysine	0.2222
p.S273T	ACH-000961	Endometrial/Uterine Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.6005
p.S273T	ACH-000995	Leukemia	CCLE	PATSS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.6005
p.A263V	ACH-000973	Bladder Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1389
p.A294P	ACH-001610	Brain Cancer	CCLE	PTPPST	DEG_SCF_FBW7_1	300:305	Mutation rewiring degron network	0.1667
p.A271S	ACH-001619	Gallbladder Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.6477

Kaplan plot for PCGF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCGF2

UniProt ID: P35227

Entrez ID: 7703

Protein name: Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCGF2 in