DegronMD

Uniprot ID: P35227

Source protein: Polycomb group RING finger protein 2

Source gene: PCGF2

Class: DEG_SPOP_SBC_1

Location: 270:274

E3 ligase: SPOP

DEGRON score: 0.9677

ASA_SCORE: 88.04

COIL: 0.9326

CONS_SCORE: 0.4256

DSS_SCORE: 0.709

HELIX: 0.0366

FCONS_SCORE: 1.0675

RIG_SCORE: 0.577

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A271P	TCGA-42-2589	OV	TCGA	PATSS	DEG_SPOP_SBC_1	0.6392
p.A271P	DO31130	OV	ICGC	PATSS	DEG_SPOP_SBC_1	0.6392
p.A271V	TCGA-AX-A1CE	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	0.5825
p.A271V	DO42280	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	0.5825
p.D261N	TCGA-AX-A2HC	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	0.0833
p.D261N	TCGA-BR-8078	STAD	TCGA	PATSS	DEG_SPOP_SBC_1	0.0833
p.D261N	DO38288	STAD	ICGC	PATSS	DEG_SPOP_SBC_1	0.0833
p.D261N	DO41572	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	0.0833
p.D261N	ACH-000989	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.0833
p.S278N	TCGA-AX-A2HD	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	0.2222
p.S278N	DO42608	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	0.2222
p.P264S	TCGA-CK-4951	COAD	TCGA	PATSS	DEG_SPOP_SBC_1	0.1667
p.P264S	DO10582	COAD	ICGC	PATSS	DEG_SPOP_SBC_1	0.1667
p.P270L	TCGA-DD-A1EL	LIHC	TCGA	PATSS	DEG_SPOP_SBC_1	0.7582
p.P270L	DO23048	LIHC	ICGC	PATSS	DEG_SPOP_SBC_1	0.7582
p.A271T	TCGA-DF-A2KN	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	0.6028
p.A271T	DO223282	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	0.6028
p.T281P	ACH-000415	Head and Neck Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.1389
p.K262R	ACH-000650	Skin Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.2222
p.S273T	ACH-000961	Endometrial/Uterine Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.6005
p.S273T	ACH-000995	Leukemia	CCLE	PATSS	DEG_SPOP_SBC_1	0.6005
p.A263V	ACH-000973	Bladder Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.1389
p.A271S	ACH-001619	Gallbladder Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.6477

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NGG8	Photoreceptor cilium actin regulator	DEG_SPOP_SBC_1	1125:1129	PATSS	SPOP	0.9621	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	907:911	PATSS	SPOP	0.9948	More...
O60504	Vinexin	DEG_SPOP_SBC_1	189:193	PATSS	SPOP	0.9439	More...
O75081	Protein CBFA2T3	DEG_SPOP_SBC_1	152:156	PATSS	SPOP	0.7702	More...
P28908	Tumor necrosis factor receptor superfamily member 8	DEG_SPOP_SBC_1	184:188	PATSS	SPOP	0.9966	More...
P31270	Homeobox protein Hox-A11	DEG_SPOP_SBC_1	187:191	PATSS	SPOP	0.8903	More...
P35227	Polycomb group RING finger protein 2	DEG_SPOP_SBC_1	270:274	PATSS	SPOP	0.9677	More...
P40200	T-cell surface protein tactile	DEG_SPOP_SBC_1	412:416	PATSS	SPOP	0.9237	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	232:236	PATSS	SPOP	0.8979	More...
P54252	Ataxin-3	DEG_SPOP_SBC_1	319:323	PATSS	SPOP	0.9966	More...
Q03112	Histone-lysine N-methyltransferase MECOM	DEG_SPOP_SBC_1	49:53	PATSS	SPOP	0.9868	More...
Q14687	Genetic suppressor element 1	DEG_SPOP_SBC_1	44:48	PATSS	SPOP	0.9439	More...
Q5SSJ5	Heterochromatin protein 1-binding protein 3	DEG_SPOP_SBC_1	87:91	PATSS	SPOP	0.9842	More...
Q63HK5	Teashirt homolog 3	DEG_SPOP_SBC_1	815:819	PATSS	SPOP	0.9964	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	892:896	PATSS	SPOP	0.9948	More...
Q8IXZ2	Zinc finger CCCH domain-containing protein 3	DEG_SPOP_SBC_1	364:368	PATSS	SPOP	0.9027	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1004:1008	PATSS	SPOP	0.9683	More...
Q92502	StAR-related lipid transfer protein 8	DEG_SPOP_SBC_1	61:65	PATSS	SPOP	0.8873	More...
Q92581	Sodium/hydrogen exchanger 6	DEG_SPOP_SBC_1	611:615	PATSS	SPOP	0.9967	More...
Q96CB8	Integrator complex subunit 12	DEG_SPOP_SBC_1	321:325	PATSS	SPOP	0.8945	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	930:934	PATSS	SPOP	0.9895	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1357:1361	PATSS	SPOP	0.96	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	617:621	PATSS	SPOP	0.9725	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	619:623	PATSS	SPOP	0.9524	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1889:1893	PATSS	SPOP	0.9045	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4232:4236	PATSS	SPOP	0.6101	More...
Q9HCE9	Anoctamin-8	DEG_SPOP_SBC_1	939:943	PATSS	SPOP	0.7199	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	521:525	PATSS	SPOP	0.994	More...
Q9UKP3	Integrin beta-1-binding protein 2	DEG_SPOP_SBC_1	78:82	PATSS	SPOP	0.9254	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	637:641	PATSS	SPOP	0.7297	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	774:778	PATSS	SPOP	0.9112	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	514:518	PATSS	SPOP	0.985	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	563:567	PATSS	SPOP	0.9988	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	835:839	PATSS	SPOP	0.9635	More...
Q3SYA9	Putative POM121-like protein 1	DEG_SPOP_SBC_1	333:337	PATSS	SPOP	0.9106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATSS

Degron related mutations and impact score

Drug responses associated with PCGF2 mutations

All proteins holding degron of PATSS