DegronMD - O60504(SORBS3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A335S	TCGA-B0-5115	KIRC	TCGA	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0556
p.A335S	DO18761	KIRC	ICGC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0556
p.H185R	TCGA-EK-A2PM	CESC	TCGA	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.H185R	DO49941	CESC	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.D181E	DO224765	BRCA	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1111
p.A198S	DO233089	GACA	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1944
p.R190C	DO233791	GACA	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.8301
p.R314M	DO219054	HNSC	ICGC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1389
p.H328R	DO228562	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.25
p.H328R	DO229036	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.25
p.S197I	DO229019	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.S201Y	DO229040	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1111
p.G182C	DO229008	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1389
p.P189S	DO45482	LUSC	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.6752
p.R197C	DO46348	OV	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.R196C	DO38723	STAD	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.25
p.R196C	DO47757	STAD	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.25
p.G182S	DO41638	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1389
p.G182S	DO42528	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1389
p.A200T	DO42673	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1389
p.Q316H	DO42665	UCEC	ICGC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1944
p.S334F	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0833
p.S334F	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0833
p.P318L	SIDM01196	Hepatocellular Carcinoma	GDSC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.25
p.P318L	ACH-000422	Liver Cancer	CCLE	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.25
p.P318L	SNU-475	liver	COSMIC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.25
p.A335T	SIDM00327	Hodgkin's Lymphoma	GDSC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0556
p.A335T	SIDM01463	Endometrial Carcinoma	GDSC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0556
p.A335T	ACH-000397	Endometrial/Uterine Cancer	CCLE	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0556
p.A335T	ACH-000754	Lymphoma	CCLE	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0556
p.A335T	L-428	haematopoietic and lymphoid tissue	COSMIC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0556
p.H328Y	SIDM01051	Ovarian Carcinoma	GDSC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.25
p.H328Y	ACH-000936	Ovarian Cancer	CCLE	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.25
p.H328Y	EFO-27	ovary	COSMIC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.25
p.A195T	SK-MEL-31	skin	COSMIC	PATSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2778
p.R314S	COR-L32	lung	COSMIC	AWSSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1389

Kaplan plot for SORBS3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SORBS3

UniProt ID: O60504

Entrez ID: 10174

Protein name: Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SORBS3 in