DegronMD

Uniprot ID: O60504

Source protein: Vinexin

Source gene: SORBS3

Class: DEG_SPOP_SBC_1

Location: 321:325

E3 ligase: SPOP

DEGRON score: 0.8929

ASA_SCORE: 72.6

COIL: 0.7824

CONS_SCORE: 0.4276

DSS_SCORE: 0.5035

HELIX: 0.1794

FCONS_SCORE: 1.0119

RIG_SCORE: 0.5848

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A335S	TCGA-B0-5115	KIRC	TCGA	AWSSS	DEG_SPOP_SBC_1	0.0556
p.A335S	DO18761	KIRC	ICGC	AWSSS	DEG_SPOP_SBC_1	0.0556
p.R314M	DO219054	HNSC	ICGC	AWSSS	DEG_SPOP_SBC_1	0.1389
p.H328R	DO228562	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	0.25
p.H328R	DO229036	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	0.25
p.Q316H	DO42665	UCEC	ICGC	AWSSS	DEG_SPOP_SBC_1	0.1944
p.S334F	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	AWSSS	DEG_SPOP_SBC_1	0.0833
p.S334F	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	AWSSS	DEG_SPOP_SBC_1	0.0833
p.P318L	SIDM01196	Hepatocellular Carcinoma	GDSC	AWSSS	DEG_SPOP_SBC_1	0.25
p.P318L	ACH-000422	Liver Cancer	CCLE	AWSSS	DEG_SPOP_SBC_1	0.25
p.P318L	SNU-475	liver	COSMIC	AWSSS	DEG_SPOP_SBC_1	0.25
p.A335T	SIDM00327	Hodgkin's Lymphoma	GDSC	AWSSS	DEG_SPOP_SBC_1	0.0556
p.A335T	SIDM01463	Endometrial Carcinoma	GDSC	AWSSS	DEG_SPOP_SBC_1	0.0556
p.A335T	ACH-000397	Endometrial/Uterine Cancer	CCLE	AWSSS	DEG_SPOP_SBC_1	0.0556
p.A335T	ACH-000754	Lymphoma	CCLE	AWSSS	DEG_SPOP_SBC_1	0.0556
p.A335T	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	AWSSS	DEG_SPOP_SBC_1	0.0556
p.H328Y	SIDM01051	Ovarian Carcinoma	GDSC	AWSSS	DEG_SPOP_SBC_1	0.25
p.H328Y	ACH-000936	Ovarian Cancer	CCLE	AWSSS	DEG_SPOP_SBC_1	0.25
p.H328Y	EFO-27	ovary	COSMIC	AWSSS	DEG_SPOP_SBC_1	0.25
p.R314S	COR-L32	lung	COSMIC	AWSSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60504	Vinexin	DEG_SPOP_SBC_1	321:325	AWSSS	SPOP	0.8929	More...
Q3V6T2	Girdin	DEG_SPOP_SBC_1	1634:1638	AWSSS	SPOP	0.9294	More...
Q6ZN44	Netrin receptor UNC5A	DEG_SPOP_SBC_1	128:132	AWSSS	SPOP	0.6965	More...
Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	DEG_SPOP_SBC_1	1186:1190	AWSSS	SPOP	0.8674	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons