DegronMD - Q3V6T2(CCDC88A)

FUNCTION: Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:20462955, PubMed:16139227, PubMed:19211784, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1588N	TCGA-17-Z026	LUAD	TCGA	DSGRTST	DEG_SCF_TRCP1_1	1589:1595	Mutation rewiring degron network	0.3056
p.Q1643K	TCGA-28-1750	GBM	TCGA	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1944
p.Q1643K	DO10930	GBM	ICGC	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1944
p.A1530V	TCGA-4Z-AA84	BLCA	TCGA	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation altering degron motif	0.6936
p.A1530V	DO218988	BLCA	ICGC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation altering degron motif	0.6936
p.A1530V	DO232761	PBCA	ICGC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation altering degron motif	0.6936
p.Q1643R	TCGA-5M-AAT6	COAD	TCGA	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1944
p.Q1643R	DO223703	COAD	ICGC	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1944
p.H1631N	TCGA-78-7535	LUAD	TCGA	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1667
p.H1631N	TCGA-78-7535	LUAD	TCGA	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.25
p.H1631N	DO24860	LUAD	ICGC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1667
p.H1631N	DO24860	LUAD	ICGC	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.25
p.G220D	TCGA-A6-6653	COAD	TCGA	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.6087
p.G220D	DO10373	COAD	ICGC	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.6087
p.R371H	TCGA-A6-6781	COAD	TCGA	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.0556
p.R371H	DO8447	COAD	ICGC	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.0556
p.L592I	TCGA-AA-3510	COAD	TCGA	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.2778
p.L592I	TCGA-AN-A046	BRCA	TCGA	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.2778
p.L592I	TCGA-CA-6717	COAD	TCGA	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.2778
p.L592I	DO1285	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.2778
p.L592I	DO7783	COAD	ICGC	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.2778
p.L592I	DO8264	COAD	ICGC	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.2778
p.E1624D	TCGA-AP-A056	UCEC	TCGA	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation altering degron motif	0.6758
p.E1624D	DO43971	UCEC	ICGC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation altering degron motif	0.6758
p.R371C	TCGA-AP-A0LM	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.0556
p.R371C	TCGA-FI-A2D5	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.0556
p.R371C	DO43306	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.0556
p.R371C	DO41331	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.0556
p.E383D	TCGA-AX-A05Z	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation altering degron motif	0.6758
p.E383D	DO40884	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation altering degron motif	0.6758
p.F1531L	TCGA-AX-A2HC	UCEC	TCGA	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation altering degron motif	0.6981
p.F1531L	DO41572	UCEC	ICGC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation altering degron motif	0.6981
p.H593Y	TCGA-AX-A2HC	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.25
p.H593Y	DO41572	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.25
p.D584N	TCGA-B5-A1MR	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.2778
p.D584N	DO223578	CLLE	ICGC	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.2778
p.D584N	DO41758	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.2778
p.E379Q	TCGA-C5-A8XK	CESC	TCGA	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.2778
p.E379Q	DO49904	CESC	ICGC	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.2778
p.H222R	TCGA-CA-6717	COAD	TCGA	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.7133
p.H222R	DO8264	COAD	ICGC	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.7133
p.I212V	TCGA-CC-5258	LIHC	TCGA	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1944
p.I212V	TCGA-DD-A1EE	LIHC	TCGA	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1944
p.I212V	DO22857	LIHC	ICGC	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1944
p.I212V	DO22881	LIHC	ICGC	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1944
p.I212V	DO23266	LINC	ICGC	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.1944
p.D393E	TCGA-CC-A8HT	LIHC	TCGA	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.1111
p.D393E	DO52187	LIHC	ICGC	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.1111
p.E379K	TCGA-CV-7243	HNSC	TCGA	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.2778
p.E379K	DO15382	HNSC	ICGC	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.2778
p.R1411L	TCGA-D3-A3CE	SKCM	TCGA	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation rewiring degron network	0.1389
p.R1411L	DO37405	SKCM	ICGC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation rewiring degron network	0.1389
p.G1590A	TCGA-D7-6528	STAD	TCGA	DSGRTST	DEG_SCF_TRCP1_1	1589:1595	Mutation altering degron motif	0.754
p.G1590A	DO38547	STAD	ICGC	DSGRTST	DEG_SCF_TRCP1_1	1589:1595	Mutation altering degron motif	0.754
p.R1591T	TCGA-DK-AA6L	BLCA	TCGA	DSGRTST	DEG_SCF_TRCP1_1	1589:1595	Mutation altering degron motif	0.7876
p.R1591T	DO219002	BLCA	ICGC	DSGRTST	DEG_SCF_TRCP1_1	1589:1595	Mutation altering degron motif	0.7876
p.Q1614H	TCGA-DM-A0XD	COAD	TCGA	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1667
p.Q1614H	DO10228	COAD	ICGC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1667
p.E1632D	TCGA-DU-6392	LGG	TCGA	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1389
p.E1632D	TCGA-DU-6392	LGG	TCGA	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.2778
p.E1632D	DO22237	LGG	ICGC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1389
p.E1632D	DO22237	LGG	ICGC	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.2778
p.S374F	TCGA-DU-6392	LGG	TCGA	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.1389
p.S374F	DO22237	LGG	ICGC	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.1389
p.D1630G	TCGA-E6-A1LX	UCEC	TCGA	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1944
p.D1630G	TCGA-E6-A1LX	UCEC	TCGA	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.2222
p.D1630G	DO41020	UCEC	ICGC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1944
p.D1630G	DO41020	UCEC	ICGC	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.2222
p.S1626G	TCGA-HE-7128	KIRP	TCGA	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.3056
p.S1626G	TCGA-HE-7128	KIRP	TCGA	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1111
p.S1626G	DO20796	KIRP	ICGC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.3056
p.S1626G	DO20796	KIRP	ICGC	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1111
p.H226Y	TCGA-HT-8010	LGG	TCGA	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.3056
p.H226Y	DO22239	LGG	ICGC	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.3056
p.S374Y	TCGA-KQ-A41N	BLCA	TCGA	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.1389
p.S374Y	DO223588	BLCA	ICGC	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.1389
p.L224V	TCGA-MV-A51V	BLCA	TCGA	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.5654
p.L224V	DO474	BLCA	ICGC	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.5654
p.L1526S	TCGA-XF-A8HG	BLCA	TCGA	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation altering degron motif	0.7667
p.L1526S	DO49802	BLCA	ICGC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation altering degron motif	0.7667
p.D393V	TCGA-XF-AAMX	BLCA	TCGA	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.1111
p.D393V	DO51939	BLCA	ICGC	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation rewiring degron network	0.1111
p.D219N	DO218176	BRCA	ICGC	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.5821
p.S1597N	DO222946	BTCA	ICGC	DSGRTST	DEG_SCF_TRCP1_1	1589:1595	Mutation rewiring degron network	0.2778
p.R1413H	DO233903	GACA	ICGC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation rewiring degron network	0.1944
p.S1635Y	DO228974	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation altering degron motif	0.712
p.N384K	DO228976	LICA	ICGC	EKENL	DEG_APCC_KENBOX_2	381:385	Mutation altering degron motif	0.6918
p.D1630E	DO229018	LICA	ICGC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1944
p.D1630E	DO229018	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.2222
p.N1613K	DO229022	LICA	ICGC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1389
p.A578E	DO229031	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation rewiring degron network	0.1111
p.R1423S	DO229034	LICA	ICGC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation altering degron motif	0.7427
p.P1617Q	DO229035	LICA	ICGC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.25
p.R1413C	DO229054	LICA	ICGC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation rewiring degron network	0.1944
p.S1626R	DO229009	LICA	ICGC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.3056
p.S1626R	DO229009	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1111
p.A1535D	DO229009	LICA	ICGC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.2222
p.E588D	DO231702	LINC	ICGC	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation altering degron motif	0.6758
p.T1594A	DO45213	LIRI	ICGC	DSGRTST	DEG_SCF_TRCP1_1	1589:1595	Mutation altering degron motif	0.7139
p.D1408G	DO28093	OV	ICGC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation substituting flanking lysine	0.1667
p.P1617L	DO33008	PACA	ICGC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.25
p.R218W	DO228138	PBCA	ICGC	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.8634
p.V1579G	DO232761	PBCA	ICGC	DSGRTST	DEG_SCF_TRCP1_1	1589:1595	Mutation rewiring degron network	0.0556
p.R1411W	DO232761	PBCA	ICGC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation rewiring degron network	0.1389
p.S1640T	SIDM00615	Hepatocellular Carcinoma	GDSC	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.2778
p.S1640T	JHH-6	liver	COSMIC	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.2778
p.F1538C	SIDM00611	Kidney Carcinoma	GDSC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.1389
p.F1538C	KMRC-1	kidney	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.1389
p.N1613I	SIDM00845	Burkitt's Lymphoma	GDSC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1389
p.V1611A	SIDM00523	Small Cell Lung Carcinoma	GDSC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.0833
p.V1611A	DMS-53	lung	COSMIC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.0833
p.T1422A	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation altering degron motif	0.7139
p.T1422A	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation altering degron motif	0.7139
p.F1430C	SIDM00118	Colorectal Carcinoma	GDSC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation rewiring degron network	0.1944
p.F1430C	HCC2998	large intestine	COSMIC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation rewiring degron network	0.1944
p.V1541I	SIDM01412	Oral Cavity Carcinoma	GDSC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.0556
p.P1421R	SIDM01611	Endometrial Carcinoma	GDSC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation altering degron motif	0.7512
p.Q1618H	SIDM01665	Colorectal Carcinoma	GDSC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.2778
p.Q1591H	ACH-000089	Colon/Colorectal Cancer	CCLE	DSGRTST	DEG_SCF_TRCP1_1	1589:1595	Mutation altering degron motif	0.7582
p.S1613T	ACH-000217	Liver Cancer	CCLE	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1389
p.S1613T	ACH-001495	Endometrial/Uterine Cancer	CCLE	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1389
p.S1613T	JHH-6	liver	COSMIC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1389
p.P234S	ACH-000635	Ovarian Cancer	CCLE	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.0833
p.V1584A	ACH-000698	Lung Cancer	CCLE	DSGRTST	DEG_SCF_TRCP1_1	1589:1595	Mutation rewiring degron network	0.1944
p.V1584A	DMS-53	lung	COSMIC	DSGRTST	DEG_SCF_TRCP1_1	1589:1595	Mutation rewiring degron network	0.1944
p.V1514I	ACH-000762	Head and Neck Cancer	CCLE	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.0833
p.T1635I	ACH-000764	Gastric Cancer	CCLE	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation altering degron motif	0.7078
p.G1519A	ACH-000786	Lymphoma	CCLE	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.2222
p.G1519A	ACH-000992	Head and Neck Cancer	CCLE	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.2222
p.G1519A	ACH-001067	Brain Cancer	CCLE	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.2222
p.G1519A	Daudi	haematopoietic and lymphoid tissue	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.2222
p.Q1540E	ACH-000920	Leukemia	CCLE	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.0833
p.Q1540E	CML-T1	haematopoietic and lymphoid tissue	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.0833
p.P1422R	ACH-000996	Endometrial/Uterine Cancer	CCLE	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation altering degron motif	0.7512
p.F1431C	ACH-001081	Colon/Colorectal Cancer	CCLE	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation rewiring degron network	0.1667
p.F1431C	HCC2998	large intestine	COSMIC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation rewiring degron network	0.1667
p.S1417Y	ACH-001109	Rhabdoid	CCLE	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation blocking phosphorylation signal	0.75
p.K1523T	ACH-001127	Leukemia	CCLE	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation altering degron motif	0.7306
p.K1523T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation altering degron motif	0.7306
p.K597R	ACH-002065	Sarcoma	CCLE	EKENK	DEG_APCC_KENBOX_2	586:590	Mutation substituting flanking lysine	0.25
p.K1522T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.3056
p.T1423A	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation altering degron motif	0.6028
p.S1641T	JHH-6	liver	COSMIC	AWSSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.25
p.V1612A	DMS-53	lung	COSMIC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1111
p.E207K	KINGS-1	central nervous system	COSMIC	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation rewiring degron network	0.0556
p.S1612T	JHH-6	liver	COSMIC	SHSSGE	DEG_Kelch_Keap1_1	1620:1625	Mutation rewiring degron network	0.1111
p.S225L	SNU-81	large intestine	COSMIC	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.7667
p.F1539C	KMRC-1	kidney	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.1111
p.V1583A	DMS-53	lung	COSMIC	DSGRTST	DEG_SCF_TRCP1_1	1589:1595	Mutation blocking phosphorylation signal	0.6111
p.L224I	SNU-1040	large intestine	COSMIC	ERDGLHFLP	DEG_APCC_DBOX_1	217:225	Mutation altering degron motif	0.6063
p.G1518A	Daudi	haematopoietic and lymphoid tissue	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.1944
p.V1429I	JSC-1	haematopoietic and lymphoid tissue	COSMIC	LTLTPTRS	DEG_SCF_FBW7_1	1418:1425	Mutation rewiring degron network	0.2222
p.Q1539E	CML-T1	haematopoietic and lymphoid tissue	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	1523:1531	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC88A

UniProt ID: Q3V6T2

Entrez ID: 55704

Protein name: Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC88A in