DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ERDGLHFLP
Uniprot ID:
Q3V6T2
Source protein:
Girdin
Source gene:
CCDC88A
Class:
DEG_APCC_DBOX_1
Location:
217:225
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5352
ASA_SCORE:
105.6444
COIL:
0.507
CONS_SCORE:
0.7384
DSS_SCORE:
0.5298
HELIX:
0.4817
FCONS_SCORE:
1.0555
RIG_SCORE:
0.6775
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G220D
TCGA-A6-6653
COAD
TCGA
ERDGLHFLP
DEG_APCC_DBOX_1
0.6087
p.G220D
DO10373
COAD
ICGC
ERDGLHFLP
DEG_APCC_DBOX_1
0.6087
p.H222R
TCGA-CA-6717
COAD
TCGA
ERDGLHFLP
DEG_APCC_DBOX_1
0.7133
p.H222R
DO8264
COAD
ICGC
ERDGLHFLP
DEG_APCC_DBOX_1
0.7133
p.I212V
TCGA-CC-5258
LIHC
TCGA
ERDGLHFLP
DEG_APCC_DBOX_1
0.1944
p.I212V
TCGA-DD-A1EE
LIHC
TCGA
ERDGLHFLP
DEG_APCC_DBOX_1
0.1944
p.I212V
DO22857
LIHC
ICGC
ERDGLHFLP
DEG_APCC_DBOX_1
0.1944
p.I212V
DO22881
LIHC
ICGC
ERDGLHFLP
DEG_APCC_DBOX_1
0.1944
p.I212V
DO23266
LINC
ICGC
ERDGLHFLP
DEG_APCC_DBOX_1
0.1944
p.H226Y
TCGA-HT-8010
LGG
TCGA
ERDGLHFLP
DEG_APCC_DBOX_1
0.3056
p.H226Y
DO22239
LGG
ICGC
ERDGLHFLP
DEG_APCC_DBOX_1
0.3056
p.L224V
TCGA-MV-A51V
BLCA
TCGA
ERDGLHFLP
DEG_APCC_DBOX_1
0.5654
p.L224V
DO474
BLCA
ICGC
ERDGLHFLP
DEG_APCC_DBOX_1
0.5654
p.D219N
DO218176
BRCA
ICGC
ERDGLHFLP
DEG_APCC_DBOX_1
0.5821
p.R218W
DO228138
PBCA
ICGC
ERDGLHFLP
DEG_APCC_DBOX_1
0.8634
p.P234S
ACH-000635
Ovarian Cancer
CCLE
ERDGLHFLP
DEG_APCC_DBOX_1
0.0833
p.E207K
KINGS-1
central_nervous_system
COSMIC
ERDGLHFLP
DEG_APCC_DBOX_1
0.0556
p.S225L
SNU-81
large_intestine
COSMIC
ERDGLHFLP
DEG_APCC_DBOX_1
0.7667
p.L224I
SNU-1040
large_intestine
COSMIC
ERDGLHFLP
DEG_APCC_DBOX_1
0.6063
Drug responses associated with CCDC88A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ERDGLHFLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q3V6T2
Girdin
DEG_APCC_DBOX_1
217:225
ERDGLHFLP
APC,CDC20,FZR1
0.5352
More...