DegronMD

Uniprot ID: Q3V6T2

Source protein: Girdin

Source gene: CCDC88A

Class: DEG_APCC_DBOX_1

Location: 1523:1531

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8808

ASA_SCORE: 100.7111

COIL: 0.5118

CONS_SCORE: 0.6812

DSS_SCORE: 0.3878

HELIX: 0.4452

FCONS_SCORE: 1.0504

RIG_SCORE: 0.7789

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1530V	TCGA-4Z-AA84	BLCA	TCGA	RRKELGAMA	DEG_APCC_DBOX_1	0.6936
p.A1530V	DO218988	BLCA	ICGC	RRKELGAMA	DEG_APCC_DBOX_1	0.6936
p.A1530V	DO232761	PBCA	ICGC	RRKELGAMA	DEG_APCC_DBOX_1	0.6936
p.F1531L	TCGA-AX-A2HC	UCEC	TCGA	RRKELGAMA	DEG_APCC_DBOX_1	0.6981
p.F1531L	DO41572	UCEC	ICGC	RRKELGAMA	DEG_APCC_DBOX_1	0.6981
p.L1526S	TCGA-XF-A8HG	BLCA	TCGA	RRKELGAMA	DEG_APCC_DBOX_1	0.7667
p.L1526S	DO49802	BLCA	ICGC	RRKELGAMA	DEG_APCC_DBOX_1	0.7667
p.A1535D	DO229009	LICA	ICGC	RRKELGAMA	DEG_APCC_DBOX_1	0.2222
p.F1538C	SIDM00611	Kidney Carcinoma	GDSC	RRKELGAMA	DEG_APCC_DBOX_1	0.1389
p.F1538C	KMRC-1	kidney	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	0.1389
p.V1541I	SIDM01412	Oral Cavity Carcinoma	GDSC	RRKELGAMA	DEG_APCC_DBOX_1	0.0556
p.V1514I	ACH-000762	Head and Neck Cancer	CCLE	RRKELGAMA	DEG_APCC_DBOX_1	0.0833
p.G1519A	ACH-000786	Lymphoma	CCLE	RRKELGAMA	DEG_APCC_DBOX_1	0.2222
p.G1519A	ACH-000992	Head and Neck Cancer	CCLE	RRKELGAMA	DEG_APCC_DBOX_1	0.2222
p.G1519A	ACH-001067	Brain Cancer	CCLE	RRKELGAMA	DEG_APCC_DBOX_1	0.2222
p.G1519A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	0.2222
p.Q1540E	ACH-000920	Leukemia	CCLE	RRKELGAMA	DEG_APCC_DBOX_1	0.0833
p.Q1540E	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	0.0833
p.K1523T	ACH-001127	Leukemia	CCLE	RRKELGAMA	DEG_APCC_DBOX_1	0.7306
p.K1523T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	0.7306
p.K1522T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	0.3056
p.F1539C	KMRC-1	kidney	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	0.1111
p.G1518A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	0.1944
p.Q1539E	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	RRKELGAMA	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRKELGAMA

Degron related mutations and impact score

Drug responses associated with CCDC88A mutations

All proteins holding degron of RRKELGAMA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3V6T2	Girdin	DEG_APCC_DBOX_1	1523:1531	RRKELGAMA	APC,CDC20,FZR1	0.8808	More...