DegronMD

Uniprot ID: Q3V6T2

Source protein: Girdin

Source gene: CCDC88A

Class: DEG_APCC_KENBOX_2

Location: 586:590

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.693

ASA_SCORE: 114.34

COIL: 0.0126

CONS_SCORE: 0.6954

DSS_SCORE: 0.3845

HELIX: 0.988

FCONS_SCORE: 1.0387

RIG_SCORE: 0.747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L592I	TCGA-AA-3510	COAD	TCGA	EKENK	DEG_APCC_KENBOX_2	0.2778
p.L592I	TCGA-AN-A046	BRCA	TCGA	EKENK	DEG_APCC_KENBOX_2	0.2778
p.L592I	TCGA-CA-6717	COAD	TCGA	EKENK	DEG_APCC_KENBOX_2	0.2778
p.L592I	DO1285	BRCA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.2778
p.L592I	DO7783	COAD	ICGC	EKENK	DEG_APCC_KENBOX_2	0.2778
p.L592I	DO8264	COAD	ICGC	EKENK	DEG_APCC_KENBOX_2	0.2778
p.H593Y	TCGA-AX-A2HC	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	0.25
p.H593Y	DO41572	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	0.25
p.D584N	TCGA-B5-A1MR	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	0.2778
p.D584N	DO223578	CLLE	ICGC	EKENK	DEG_APCC_KENBOX_2	0.2778
p.D584N	DO41758	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	0.2778
p.A578E	DO229031	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	0.1111
p.E588D	DO231702	LINC	ICGC	EKENK	DEG_APCC_KENBOX_2	0.6758
p.K597R	ACH-002065	Sarcoma	CCLE	EKENK	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07550	Beta-2 adrenergic receptor	DEG_APCC_KENBOX_2	371:375	EKENK	APC,CDC20,FZR1	0.9351	More...
P17844	Probable ATP-dependent RNA helicase DDX5	DEG_APCC_KENBOX_2	339:343	EKENK	APC,CDC20,FZR1	0.5974	More...
P48681	Nestin	DEG_APCC_KENBOX_2	590:594	EKENK	APC,CDC20,FZR1	0.979	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	586:590	EKENK	APC,CDC20,FZR1	0.693	More...
Q6UB98	Ankyrin repeat domain-containing protein 12	DEG_APCC_KENBOX_2	1632:1636	EKENK	APC,CDC20,FZR1	0.9775	More...
Q96HR8	H/ACA ribonucleoprotein complex non-core subunit NAF1	DEG_APCC_KENBOX_2	163:167	EKENK	APC,CDC20,FZR1	0.962	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	589:593	EKENK	APC,CDC20,FZR1	0.9822	More...
Q53SF7	Cordon-bleu protein-like 1	DEG_APCC_KENBOX_2	234:238	EKENK	APC,CDC20,FZR1	0.9886	More...
Q5T9S5	Coiled-coil domain-containing protein 18	DEG_APCC_KENBOX_2	281:285	EKENK	APC,CDC20,FZR1	0.6092	More...
Q92628	Uncharacterized protein KIAA0232	DEG_APCC_KENBOX_2	254:258	EKENK	APC,CDC20,FZR1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons